Advances in Lipid Research

Advances in Lipid Research, Volume 6 provides information pertinent to brain cholesterol and myelin lipids. This book reviews the various aspects of the physiology, chemistry, and biochemistry of lipids.

Organized into seven chapters, this volume begins with an overview of the separation of lipoproteins and discusses lipid metabolism in microorganisms. This text then provides a discussion of lipid metabolism in mycoplasmas. Other chapters consider the various aspects of metabolism of the lipid quinones and explore the relationship between lipids and atherosclerosis as a continuing source of biochemical, medical, and nutritional interest. This book discusses as well a comparative aspect of the development of atherosclerosis and explains the chemistry of bile acids. The final chapter deals with the aspects of steroid separations as well as with regard to separation of other metabolites that may influence lipid metabolism.

This book is a valuable resource for biologists, biochemists, scientists, and research workers.

Contenu

List of Contributors
Preface
Contents of Previous Volumes
Practical Methods for Plasma Lipoprotein Analysis
I. Introduction
II. The Physicochemical Basis of Lipoprotein Fractionation
III. Methods Used in Lipoprotein Separations
IV. Practical Methods for Lipoprotein Analysis
V. Conclusions
References
The Lipids of Mycoplasma
I. Introduction
II. Lipid Composition and Cellular Location
III. The Nature of Mycoplasmal Lipids
IV. Lipid Nutrition of Mycoplasma
V. Biosynthesis of Lipids by Mycoplasma
VI. Metabolism of Lipids by Mycoplasma
VII. Functional Roles of Lipids in Mycoplasma
Note Added in Proof
References
Lipid Quinones
I. Introduction
II. General Considerations
III. Physical and Chemical Properties
IV. Procedures of Isolation
V. Quantitative Analysis
VI. Natural Occurrence and Distribution
VII. Synthesis and Biosynthesis
VIII. Relationship to Nutrition
IX. Metabolic Role of Lipid Quinones
References
Comparative Pathogenetic Patterns in Atherosclerosis
I. Introduction
II. Lipoprotein Accumulation in and Injury to Medial Smooth Muscle Cells
III. The Smooth Muscle Cell of the Artery Wall Responds by Proliferating, Migrating, and Modifying its Metabolism
IV. Smooth Muscle Cell Migration and Colonization Into or on Arterial Transplants or Prostheses
V. The Arterial Smooth Muscle Cell Produces Variable Quantities of Collagen, Elastin, Smooth Muscle Fibers, Ground Substance, and Basement Membrane
VI. Circulating Lipid-Filled Monocyte versus Lipoprotein Filtration in Atherogenesis
VII. The Role of Arterial Lipid Synthesis in the Development of Atherosclerosis in Certain Species
References
Chemistry and Metabolism of Bile Alcohols and Higher Bile Acids
I. Introduction
II. Separation and Analysis of Bile Alcohols and Higher Bile Acids
III. Chemistry of Bile Alcohols and Higher Bile Acids
IV. Biosynthesis and Metabolism of Bile Alcohols and Higher Bile Acids
V. Conclusion
References
Hydroxy Fatty Acid Metabolism in Brain
I. Background Information
II. Biosynthesis of the 2-Hydroxy Acids
III. Metabolism of 2-Hydroxy Acids
IV. Prostaglandins
V. Hydroxy Fatty Acids in Disease
References
Gas Phase Analytical Methods for the Study of Steroids
I. Introduction
II. The Practice of Gas Chromatography
III. Structure-Retention Time Relationships
IV. Separation Methods for Steroid Classes
V. Identification of Steroids by Mass Spectrometry
VI. Quantification
References
Author Index
Subject Index