Advances in Lipid Research

Advances in Lipid Research, Volume 2 provides a discussion of theories of triglyceride structure and presents a provocative comparison of in vitro versus in vivo lipid biosynthesis. This book covers brain phosphoinositide research, synthesis of phosphoglycerides, and the chemistry of lapoamino acids and phosphatidylglycerols.

Organized into eight chapters, this volume begins with an overview of the procedure for calculating the percentages of the individual triglycerides as well as for triglyceride families. This text then examines the complex field of bacterial lipids. Other chapters consider the two aspects of the relationship between lipid metabolism and atherosclerosis. This book discusses as well the lipolytic and esterolytic activity of various tissues in connection with lipid transport and its relevancy to the development of atherosclerosis. The final chapter deals with the methods best adopted for in vitro and in vivo investigations of lipid biosynthesis.

This book is a valuable resource for phospholipid chemists, biochemists, and scientists.

Contenu

Contributors to this Volume
Preface
Triglyceride Structure
I. General
II. The 1,3 Random, 2 Random Distribution Hypothesis
III. The Validity of the 1,3 Random, 2 Random Distribution Hypothesis
IV. Mechanisms
References
Bacterial Lipids
I. Introduction
II. Lipid Composition of Whole Cells
III. Intracellular Distribution of Lipids
IV. Biosynthesis of Lipid Components
References
Phosphatidylglycerols and Lipoamino Acids
I. General Introduction
II. Phosphatidylglycerols
III. Lipoamino Acids
References
The Brain Phosphoinositides
I. Introduction
II. Methods of Separation and Analysis
III. Chemistry of the Brain Inositides
IV. Enzymatic Breakdown
V. Biosynthesis
VI. Physiological Significance of Brain Inositides
References
The Synthesis of Phosphoglycerides and Some Biochemical Applications
I. Introduction
II. Synthesis of Phosphatidylcholine
III. Synthesis of Phosphatidylethanolamine
IV. Synthesis of Phosphatidylserine
V. Synthesis of Miscellaneous Types of Phosphoglycerides and Derivatives
VI. Application of Synthetic Phosphoglycerides in Biochemical Problems
VII. Concluding Comments
References
The Lipolytic and Esterolytic Activity of Blood and Tissues and Problems of Atherosclerosis
I. Introduction
II. Mast Cells, Lipid Transport, and Atherosclerosis
III. Effects of Protamine Sulfate Administration
IV. Some Observations on the Clearing Factor and Human Atherosclerosis
V. The Relationship between Lipoprotein Lipase, Postherapin Esterase, and Other "Clearing Factor Enzymes"
VI. Lipolytic and Esterolytic Activity of Tissues
VII. Concluding Remarks
References
Evaluation of Drugs Active Against Experimental Atherosclerosis
I. Introduction
II. Experimental Atherosclerosis
III. Cholesterol Synthesis Inhibitors
IV. Acceleration of Cholesterol Degradation and Excretion
V. Sterols Related to Cholesterol
VI. Estrogens and Related Compounds
VII. Androgens and Related Compounds
VIII. Thyroid Hormones and Analogs
IX. Adrenal and Pituitary Hormones
X. Hypotensive Agents
XI. Vitamins and Atherogenesis
XII. Unsaturated Fatty Acids
XIII. Lipoprotein Lipase and Heparin
XIV. Thrombosis, Fibrinolysis, and Anticoagulation
XV. Conclusions
References
Comparative Evaluation of Lipid Biosynthesis in Vitro and in Vivo
I. Introduction
II. Study of Precursors
III. The Enzymatic Systems and the Mechanisms of Synthesis
IV. Localization of Synthesis
V. The Qualitative and Quantitative Regulation of Fatty Acid Synthesis
VI. Conclusion
References
Author Index
Subject Index