Advanced Molecularly Imprinting Materials

Molecularly imprinted polymers (MIPs) are an important functional material because of their potential implications in diverse research fields. The materials have been developed for a range of uses including separation, environmental, biomedical and sensor applications. In this book, the chapters are clustered into two main sections: Strategies to be employed when using the affinity materials, and rational design of MIPs for advanced applications. In the first part, the book covers the recent advances in producing MIPs for sample design, preparation and characterizations. In the second part, the chapters demonstrate the importance and novelty of creation of recognition imprinted on the materials and surfaces for a range of microbial detection sensors in the biomedical, environmental and food safety fields as well as sensing human odor and virus monitoring systems.

Part 1: Strategies of affinity materials

• Molecularly imprinted polymers

• MIP nanomaterials

• Micro- and nanotraps for solid phase extraction

• Carbonaceous affinity nanomaterials

• Fluorescent MIPs

• MIP-based fiber optic sensors

Part 2: Rational design of MIP for advanced applications

• MIP-based biomedical and environmental sensors

• Affinity adsorbents for environmental biotechnology

• MIP in food safety

• MIP-based virus monitoring

• MIP-based drug delivery and controlled release

• Biorecognition imprints on the biosensor surfaces

• MIP-based sensing of volatile organic compounds in human body odour

• MIP-based microcantilever sensor system

Auteur

Ashutosh Tiwari is Secretary General, International Association of Advanced Materials; Chairman and Managing Director of Tekidag AB (Innotech); Associate Professor and Group Leader, Smart Materials and Biodevices at the world premier Biosensors and Bioelectronics Centre, IFM-Linköping University; Editor-in-Chief, Advanced Materials Letters; a materials chemist and docent in the Applied Physics with the specialization of Biosensors and Bioelectronics from Linköping University, Sweden. He has more than 100 peer-reviewed primary research publications in the field of materials science and nanotechnology and has edited/authored more than 35 books on advanced materials and technology.

Lokman Uzun is an Associate Professor at Hacettepe University, Department of Chemistry, Ankara,Turkey and Associate Editor of Advanced Materials Letters. He has received his PhD in 2008 from Institute of Science in (Bio)Chemistry, Hacettepe University and has published 105 papers in SCI journals. His research interests are mainly materials science, surface modification, affinity interaction, polymer science, especially molecularly imprinted polymers and their applications in biosensors, bioseparation, food safety, and environmental sciences. He has produced novel polymers to detect, separate and purify important biological molecules, remove or deplete toxic molecules such as heavy metal ions, bilirubin, antibiotics, organic pollutants, and undesired proteins from serum and aqueous solutions.

Contenu

Preface xiii

Part 1 Strategies of Affinity Materials

1 Recent Molecularly Imprinted Polymer-based Methods for Sample Preparation 3
Antonio Martín-Esteban

1.1 Introduction 3

1.2 Molecularly Imprinted Solid-phase Extraction 6

1.3 Molecularly Imprinted Solid-phase Microextraction 14

1.4 Molecularly Imprinted Stir Bar Sorptive Extraction 17

1.5 Other Formats 18

1.6 Conclusions 20

References 21

2 A Genuine Combination of Solvent-free Sample Preparation Technique and Molecularly Imprinted Nanomaterials 29
Santanu Patra, Ekta Roy, Rashmi Madhuri and Prashant K. Sharma

2.1 Introduction 30

2.2 Molecularly Imprinted Polymer Modified Fiber for Solid-phase Microextraction 40

2.3 In-tube Solid-phase Microextraction Technique 55

2.4 Monolithic Fiber 58

2.5 Micro-solid-phase Extraction 70

2.6 Stir-bar Sorptive Extraction 73

2.7 Conclusion and Future Scope 76

Acknowledgments 76

Abbreviations 77

References 78

3 Fluorescent Molecularly Imprinted Polymers 89
Kornelia Gawlitza, Wei Wan, Sabine Wagner and Knut Rurack

3.1 Introduction 89

3.2 Classes of Emitters to Endow MIPs with Fluorescence 91

3.3 Fluorescent Molecularly Imprinted Silica 108

3.4 Post-imprinting of MIPs 111

3.5 fMIPs as Labels 113

3.6 Formats for fMIPs 115

3.7 Conclusion 119

References 120

4 Molecularly Imprinted Polymer-based Micro- and Nanotraps for Solid-phase Extraction 129
Rdvan Say, Rüstem Keçili and Arzu Ersöz

4.1 Introduction 130

4.2 MIPs as SPE Materials 130

4.3 Conclusions 149

References 153

5 Imprinted Carbonaceous Nanomaterials: A Tiny Looking Big Thing in the Field of Selective and Secific Analysis 165
Ekta Roy, Santanu Patra, Rashmi Madhuri and Prashant K. Sharma

5.1 Introduction 166

5.2 Graphene-modified Imprinted Polymer 179

5.3 Carbon Nanotubes-modified Imprinted Polymer 190

5.4 Combination of graphene, CNTs, and MIPs 197

5.5 Graphene Quantum Dots and/or Carbon Dots 198

5.6 Fullerene 201

5.7 Activated carbon 202

5.8 Conclusions 203

Acknowledgments 204

List of abbreviations 204

References 205

6 Molecularly Imprinted Materials for Fiber-optic Sensor Platforms 217
Yavuz Orhan Yaman, Necdet Baaran, Kübra Karayagiz, Zafer Vatansever, Cengiz Yegin, Önder Haluk Tekba and Müfrettin Murat Sari

6.1 Introduction 218

6.2 Material Aspect: Morphology and Physical Forms of MIPs in FO Sensors 223

6.3 Molecularly Imprinting Technology for Fiber-optic Sensors 231

6.4 State-of-the-art Fiber-optic Sensors Applications Using Molecularly Imprinted Materials 268

6.5 Conclusion 273

References 274

Part 2 Rational Design of MIP for Advanced Applications

7 Molecularly Imprinted Polymer-based Sensors for Biomedical and Environmental Applications 285
Anca Florea, Oana Hosu, Bianca Ciui and Cecilia Cristea

7.1 Introduction 285

7.2 Molecularly Imprinted Polymers for Analytes of Biomedical Interest 296

7.3 Molecularly Imprinted Polymers for Analytes of Environmental Interest 306

7.4 Conclusion 314

Acknowledgments 316

References 316

8 Molecularly Imprinted Polymers: The Affinity Adsorbents for Environmental Biotechnology 327
Bo Mattiasson and Gizem Ertürk

8.1 Introduction 327

8.2 Molecularly Imprinted Polymers 329

8.3 Monomers 329

8.4 Cross-linking Agents 331

8.5 Mode of Polymerization 332

8.6 Cryogels 334

8.7 Process Technology 336 8.8 Applicatio...