Acute Leukemias

The new edition of this well-received book provides a timely update of current knowledge on the biology, disease classification, and treatment of the acute leukemias - acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Throughout, the focus is on the provision of state of the art information and guidance that will meet the needs of clinicians. Chapters have been extensively revised to take into account advances in understanding and management that have been achieved over the past few years. In addition, new chapters have been included on selection of AML patients for therapy, a broader discussion of stem cell transplantation in AML, the role of immunotherapy in ALL, the approach to newly diagnosed pediatric ALL, and the diagnosis and management of BCR-ABL-like ALL. New therapies, including investigational ones, are fully covered. As progress continues in the management of acute leukemias this book will be a valuable asset for clinicians at all levels of experience.

Auteur

Stefan H. Faderl, MD, graduated in 1990 from Ludwig-Maximilians University in Munich, Germany. After fellowship training in Medical Oncology at the MD Anderson Cancer Center, Dr. Faderl joined the Leukemia Department at MD Anderson Cancer Center, where he worked on acute and chronic leukemias and rose to the rank of full professor. During this time he was engaged in the development of several new agents for the treatment of leukemia. In 2013, Dr. Faderl took the position as Chief of Leukemia at the John Theurer Cancer Center at Hackensack University Medical Center, where he successfully grew the clinical and clinical research programs. In 2017 he transitioned to the pharmaceutical industry where he continues developmental work towards new therapies for oncology patients. Dr. Faderl is the author of numerous journal articles, book chapters, abstracts, and editorials.

Hagop M. Kantarjian, MD, is a professor and chair of the Department of Leukemia at The University of Texas MD Anderson Cancer Center in Houston, TX. Also, he is the Samsung Distinguished Leukemia Chair in Cancer Medicine and a Special Fellow on Healthcare Policies at the Rice University Baker Institute in Houston, TX and and advocates for healthcare issues pertinent to patients with cancer and leukemia.Dr Kantarjian's research focuses on translational-clinical developmental therapeutics in leukemia. In the past 3 decades, he has made several contributions that improved the prognosis and survival in patients with chronic myeloid leukemia (tyrosine kinase inhibitors, eg, imatinib, dasatinib, nilotinib, bosutinib, ponatinib which improved the 10-year survival from 20% to 90%), in acute lymphocytic leukemia (H-CVAD regimen and its derivatives; antibodies including blinatumomab and inotuzumab), the discovery of decitabine for the treatment of myelodysplastic syndrome, and of clofarabine for the treatment of leukemias, among others. His research and collaborations were the basis for the FDA approvals of several drugs in leukemia.

Elihu Estey, MD, has been involved in clinical research in acute myeloid leukemia (AML) for almost 40 years, the first 30 at MD Anderson Cancer Center in Houston, and the past 9 at the University of Washington Medical Center and the Fred Hutchinson Cancer Research Center, Seattle (UW/FHRCH). While at MD Anderson he was the first to report use of all-trans retinoic acid and arsenic trioxide without cytotoxic chemotherapy for treatment of newly diagnosed acute promyelocytic leukemia, which is now the standard worldwide. He also implemented a selection design for comparing new therapies in AML, which formed the basis for the "play-the-winner" designs used in trials in older patients. At UW/FHCRC he suggested the feasibility of early discharge from hospital after intensive induction therapy for AML. Dr. Estey coordinates UW/FHCRC non-transplant AML clinical research and has made major contributions to the development of the European LeukemiaNet AML guidelines and before that the International Working Group AML Guidelines. He regularly publishes in Blood, JCO, and Leukemia and in 2016 wrote an NEJM editorial on therapeutic implications of AML molecular subtypes.

Résumé

Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. Thus, several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia. Given our intention that the book be useful to clinicians, we pay particular attention to these advances, to management of acute leukemia in general, and to development of new therapies.

Contenu
Part I Acute Myeloid Leukemia.- Acute Myeloid Leukemia: Epidemiology and Etiology.- Clinical Presentation, Diagnosis and Classification of Acute Myedloid Leukemia.- Selection of Patients for Therapy.- Therapy of Newly Diagnosed AML.- Management of Relapsed and Refractory AML.- Stem cell Transplant in AML.- Investigational Therapies in AML.- Acute Lymphoblastic Leukemia.- Acute Lymphoblastic Leukemia: Epidemiology abnd Etiology.- Molecular Biology and Genetics.- Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification.- Therapy of Newly Diagnosed Adult ALL.- Approach to Newly Diagnosed Pediatric and AYA ALL.- The Role of Immunotherapy in ALL.- STem Cell Transplantation in the Treatment of ALL.- The Significance of Minimal Residual Disease in Acute Lymphoblastic Leukemia.- Philadelphia Chromosome - Positive Acute Lymphoblastic Leukemia.- BCR-ABL-like ALL: Diagnosis and Management.- Burkitt's Acute Lymphoblastic Leukema in Adults.- Treatment of Lymphoblastic Lymphoma in Adults.- Central Nervous System Involovment in Adult Acute Lymphocytic Leukemia.- Management of Relapsed and Refractory ALL.- Emergencies in Acute Lymphoblastic Leukema.- Investigational Therapies in ALL