ABC of Sepsis

The importance of early prevention and treatment of sepsis has
never been greater. In the UK alone sepsis contributes to more
deaths than lung cancer, from bowel cancer and breast cancer
combined, and approximately one third of patients who suffer from
severe sepsis die. The ABC of Sepsis provides a much needed
introduction and an invaluable aid in the increasing efforts to
reduce hospital infection and improve patient safety.

As growing numbers of junior medical staff experience emergency
medicine, critical care and acute medicine as part of the
Foundation Programme, there is an increasing need to develop the
skills required to treat severe sepsis. The editors are involved
with the Survive Sepsis campaign - developed to improve the
recognition, diagnosis and treatment of sepsis - and are perfectly
placed to guide junior medics, GPs, specialist nurses, critical
care nurses and primary care staff through this core aspect of
acute medicine.

Auteur
Dr Ron Daniels MB ChB FRCA
Consultant in Anaesthesia and Critical Care Lead Clinican, Critical
Care Outreach, Good Hope Hospital, Birmingham, UK
Chair: Surviving Sepsis Campaign United Kingdom Steering Committee
Survive SEPSIS Programme Director

Dr Tim Nutbeam MB ChB
Trainee in Emergency Medicine/Intensive Care Medicine
Editor: Survive SEPSIS (the educational programme of the international Surviving Sepsis Campaign)

Résumé
The importance of early prevention and treatment of sepsis has never been greater. In the UK alone sepsis contributes to more deaths than lung cancer, from bowel cancer and breast cancer combined, and approximately one third of patients who suffer from severe sepsis die. The ABC of Sepsis provides a much needed introduction and an invaluable aid in the increasing efforts to reduce hospital infection and improve patient safety. As growing numbers of junior medical staff experience emergency medicine, critical care and acute medicine as part of the Foundation Programme, there is an increasing need to develop the skills required to treat severe sepsis. The editors are involved with the Survive Sepsis campaign - developed to improve the recognition, diagnosis and treatment of sepsis - and are perfectly placed to guide junior medics, GPs, specialist nurses, critical care nurses and primary care staff through this core aspect of acute medicine.

Contenu

Contributors vii

Preface ix

1 Introduction 1
Mitchell M. Levy

2 Defining the Spectrum of Disease 5
Ron Daniels

3 Identifying the Patient with Sepsis 10
Ron Daniels

4 Serious Complications of Sepsis 15
Hentie Cilliers Tony Whitehouse and Bill Tunnicliffe

5 The Pathophysiology of Sepsis 20
Edwin Mitchell and Tony Whitehouse

6 Initial Resuscitation 25
Tim Nutbeam

7 Microbiology and Antibiotic Therapy 29
Partha De and Ron Daniels

8 Infection Prevention and Control 36
Fiona Lawrence Georgina McNamara and Clare Galvin

9 The Role of Imaging in Sepsis 42
Morgan Cleasby

10 Presentations in Medical Patients 48
Nandan Gautam

11 Presentations in Surgical Patients 57
Jonathan Stewart and Sian Abbott

12 Special Cases: The Immunocompromised Patient 62
Manos Nikolousis

13 The Role of Critical Care 68
Julian Hull

14 Monitoring the Septic Patient 73
David Stanley

15 Novel Therapies in Sepsis 78
Gavin D. Perkins and David R. Thickett

16 Approaches to Achieve Change 83
Julian F. Bion and Gordon D. Rubenfield

Index 87