Bayesian Adaptive Design for Immunotherapy and Targeted Therapy

This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-escalation study, proof-of-concept trials, and confirmatory studies with registrational. The book includes real-life examples and software to facilitate practitioners to learn and use the designs in practice.

The first book focusing on novel adaptive designs for targeted and immunotherapies Comprehensive coverage of state-of-the-art Bayesian adaptive designs, such as model-assisted designs Including many real-world trial examples

Contenu
Introduction to Adaptive Design and Delayed Outcomes.- Basics of Bayesian Statistics.- Phase I Dose-finding Design.- Phase II Design for Interim Monitoring.- Phase I-II Dose-finding Design.- Drug Combination Trial Design.- Conclusion.