Bioorganic and Enzymatic Catalysis

The book covers the most important enzymatic reactions and related catalytic bioorganic reactions using a new approach: Each enzymatic reaction type is compared with organocatalytic, organometallic and other alternative reactions, allowing the reader to understand catalytic reactions in a much-integrated way. It describes enzymatic C-C bond formation using aldolases, Claisen-type C-C bond formation involving fatty acid synthases and polyketide synthases, biomimetic cyclisations involving carbenium ions, enzymatic oxidation and C-H activation, as well as dioxygenases and oxidoreductases. With its unique approach, the book is a valuable source of information for professionals and researchers in academia and industry as well as graduate and PhD students working in the fields of organic chemistry, biochemistry, and life sciences.

Auteur
Wolf-D. Woggon is Emeritus Professor of Organic Chemistry in the Department of Chemistry at the University of Basel (Switzerland). He completed his Ph.D. in organic chemistry at the University of Zurich (Switzerland) with the late Hans Schmid. After a postdoctoral stay with Alan Battersby in Cambridge (UK), he started his independent research at the University of Zurich and completed his habilitation in 1985. In 1995, he became professor at the University of Basel. His research interests include the synthesis of enzyme models, enzymatic reaction mechanisms, isolation of new enzymes, the synthesis of vitamins, metalloporphyrins, cyclodextrins and the development of new ligand-scaffolds for metal-organic catalysis. He has served for six years as head of the Department of Chemistry at the University of Basel and for further four years as its managing director.

Texte du rabat

Direct comparison of enzymatic reactions and corresponding catalytic transformations in the laboratory Bioorganic and Enzymatic Catalysis covers the most important enzymatic reactions and related catalytic bioorganic reactions using a new approach: Each enzymatic reaction type is compared with organocatalytic, organometallic and other alternative reactions, allowing the reader to understand catalytic reactions in a much-integrated way. For example, in a chapter that describes aldolases corresponding reactions using catalytic antibodies, organocatalytic reagents and metal complexes are discussed. Written by a well-known expert in the field with more than 30 years of experience in organic and bioorganic chemistry, Bioorganic and Enzymatic Catalysis covers sample topics such as:

• Enzymatic C-C bond formation using aldolases
• Claisen-type C-C bond formation involving fatty acid synthases and polyketide synthases
• Biomimetic cyclisations involving carbenium ions
• Enzymatic oxidation and C-H activation
• Dioxygenases and oxidoreductases With its unique approach, Bioorganic and Enzymatic Catalysis is a valuable source of information for professionals and researchers in academia and industry as well as graduate and PhD students working in the fields of organic chemistry, biochemistry, and life sciences.

Contenu

1. Bioorganic and Enzymatic Catalysis: Introduction
   
   2. C-C Bond Forming Reactions Catalyzed by Enzymes and Bioorganic Systems
   3. C-C Bond Formation Involving Carbocations
   4. Reactions Catalyzed by Heme Complexes
   5. Oxidations Catalyzed by Non-Heme Complexes and other Co-Factors
   6. Carboxylases
   7. Enzymatic Oxidation
   8. Oxidoreductases
   9. Synthetic Systems that Mimic Certain Aspects of Oxidoreductases