Implementation of Personalized Precision Medicine

Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes the landscape of precision medicine as it stands in relation to implementation of individualized approaches based on the patient's unique genomic and biochemical make-up to facilitate prevention, early detection, and personalized interventions. This reference details how these lofty goals are now achievable with the science of today (and tomorrow) and provides the context and blueprint allowing researchers and clinicians to avoid, and more effectively treat, complex chronic disease. At the heart of precision medicine lies one concept that has been missing from modern medicine - the unique genetic and biochemical make-up of each individual patient. Uniquely organized, this reference will reflect this concept and provide insight into patient constitution, genetic inherited risks, current epigenetic modifications, and current biochemical state making this reference valuable to researchers and science-minded providers who modify, reverse or prevent disease progression.

Auteur
Dr Stanford MD, PhD is a physician-scientist and Fellow of the American College of Physicians. He is one of the pioneers in the field of hospital medicine. In 2002, he founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center. From 2001-2018, he was the physician of record for over 150,000 patient encounters. He was elected by his peers to be Clinical Chief of General Internal Medicine, serving in this capacity from 2017 to 2018. Advances in genomics and precision medicine inspired him to pivot again, this time to precision medicine. He completed Professional Certification in Genetics and Genomics through Stanford University in 2018. In 2018, he founded the Beverly Hills Institute for Precision Medicine and continues to present as the Chief Medical and Scientific Officer. He regularly attends and frequently speaks at precision medicine conferences, most recently at the Precision Medicine World Conference in January of 2020 Laura Kelly DAOM, MATCM, L. Ac, Dipl. OM is a nationally licensed Doctor of Oriental Medicine. She is in general practice in Los Angeles with a focus on resolving chronic disease through personalized precision medicine. This practice has expanded to include telemedicine consults with patients throughout the US as well as consults for practicing physicians on the use of genomics and nutrition in chronic disease resolution. In 2019 she founded Opal Health where she is currently CEO and CSO, creating precision prevention tools for corporate implementation as well as for the general public.

Texte du rabat
At the heart of precision medicine lies one concept missing from modern medicine - the unique genetic and biochemical make-up of each individual patient. Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes a landscape of precision medicine geared towards implementation of fully personalized approaches within precision medicine to facilitate prevention and early detection of age-related disease in each individual. This reference details how these lofty goals are now achievable with the science of today and tomorrow and provides the context, thought process and beginning blueprint to guide researchers and clinicians in more effectively considering the prevention and treatment of complex chronic disease.

Uniquely organized, this reference provides insight into creating fully personalized precision medical treatments. Chapters include conventionally considered data such as genetic inherited risk, current epigenetic modifications, and current biochemical markers but also include less conventional food for thought such as microbiome, mitochondrial function, and dna repair. This provocative landscape makes this reference a valuable addition to the literature expanding precision medicine towards personalized chronic disease prevention and treatment.

Contenu

1. Epigenetics/methylation
   
   2. Polygenic Risk Scores: A conceptual overview to add PRS to your clinical toolbox
   3. The Proteomics Revolution: Forging a New Path to Personalized Healthcare
   4. Pharmacogenetic Implementation
   5. Molecular Imaging
   6. Early quantum computing applications on the path towards precision medicine
   7. Gene Therapy: State of the Art Precision Medicine
   8. Precision Mitochondrial Medicine: Uncovering Pathways Across Diverse Diseases
   9. Antigen-specific immunotherapy: The ultimate precision medicine for treatment of autoimmune diseases
   10. The Future of Precision Diabetes: Digital Twin
   11. Precision Oncology: Indications and Challenges in the Implementation of High-throughput Sequencing in Clinical Practice
   12. Bringing "Precision" to Psychiatry: Challenges and Promises
   13. Precision Medicine in Cardiovascular Disease
   14. Precision Bone Health: A WGS Look at Bone Density
   15. Functional Nutrigenomics: A Personalized Shift in Treating Inflammation
   16. Regulating Ferroptosis: Towards Precision Treatment of Dysregulated Cell Death
   17. Precision Medicine for Brain Health and Prevention of Neurodegenerative/Neurocognitive Decline
   18. Gut Microbiome in Personalized Precision Medicine
   19. The Exposome and Detoxification: New Tools for Precision Health
   20. Unraveling Time: Longevity and DNA Repair Mechanisms
   21. Considering Ethics in Precision Medicine
   22. Personomics: The Personalization of Precision Medicine