Vitamin D. Basic Research and its Clinical Application

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Frontmatter -- Foreword -- Contents -- Chemistry, Structure, Function and Biological Assay -- Introduction -- Synthesis of Some Side Chain Analogues of Vitamin D3 Metabolites -- Structural Transformations on Vitamin D -- Distribution and Activity of a Vitamin D3 Compound in Trisetum Flavescens -- Synthesis and Biological Activity of 24R-Hydroxy-25-fluorocholecalciferol and 1a, 24R-Dihydroxy-25-fluorocholecalciferol -- The Synthesis and Biological Evaluation of Fluorinated Analoges as Probes of Vitamin Da Metabolism -- 19-Substituted-10,19-Dihydrovitamins via Hydrozirconation of Vitamin D3 -- The Synthesis of 1a, 3a-Dihydroxy-25Methylcholesta-5,7-Diene-24-OIC Acid, and of la, 3a-Dihydroxy-25 Methylcholesta-5,7-Diene -- Interconversion of Vitamin D and Trans-Vitamin D by Triplet-Sensitized Isomerization -- The Use of UV, CD, 2H-NMR Spectroscopy and Mass Spectrometry for the Investigation of Conformational Mobility of Vitamin D and Previtamin D and their Interconversion -- 25 (R), 26 and 25 (S), 26-(OH)2D3: Biological Activity in Intact and Nephrectomized Rats. Comparative Effects of 1, 25, 24 (R), 25-(OH)2D3 and I, 24 (R), 25-(OH)3D3 -- Inhibitors of Vitamin D Metabolism and Action -- C(1)-Hydroxylation of Vitamin D3 and Related Compounds -- Vitamin D3 Sulfate in Lactating normally fed Rats and Suckling Pups After Maternal Administration of 3H Vitamin D3 or 35S Vitamin D3 Sulfate -- Synthesis of Vitamin D Analogues and their Covalent Binding to Affinity Chromatographic Media -- Osteoporosis -- Calcium Absorption and Plasma 1,25 (OH)2D Levels in Post-Menopausal Osteoporosis -- Osteoporosis and Age-Related Osteopenia: Evaluation of Possible Role of Vitamin D Endocrine System in Pathogenesis of Intestinal Calcium Absorption -- Two Years Experience of Oral Treatment with 1a-Hydroxyvitamin D and Calcium in Patients with Senile or Postmenopausal Osteoporosis -- The Treatment of Osteoporosis with 24,25 Dihydroxycholecalciferol A Pilot Study -- Osteomalacic Factors in the Osteoporosis and the Treatment of Osteoporotic Patients with Vitamin D2 and 1aOHD3 -- Transcalciferan/D-Binding Protein(s) -- Biologic Significance of Genetic Variation in Human Gc (Vitamin D-Binding Protein) -- The Transport of Vitamin D -- Structure and Properties of Human Plasma Vitamin D Transport Protein (Group-Specific Component) -- Serum Vitamin D Binding and Gc Polymorphism -- Sunlight, Skin and Seasonal Effects -- Identification of in Vivo Generated Previtamin D3, Vitamin D3 and 25-Hydroxyvitamin D3 in the Vitamin D-Deficient Rats Irradiated by Ultraviolet Light -- Response of Plasma 250HD to Standardized Ultra Violet Radiation -- Effects of Sunlight Exposure on Blood Concentration of Vitamin D Derivatives in Healthy Japanese Adults -- Contribution of Skin Vitamin D3 Synthesis in Patients Receiving Total Parenteral Nutrition -- The Photo-Biochemistry of Vitamin D3 in Vivo in the Skin -- Assays for Vitamin D Metabolites -- Measurement of Plasma 1,25 (OH)2 Vitamin D by Protein Binding Assay and Radioimmunoassay -- Use of Isotope Dilution Mass Fragmentography in Vitamin D Research -- Assay of 1,25-Dihydroxyvitamin D and Other Active Vitamin D Metabolites in Serum: Application to Animals and Humans -- 24,25-Dihydoxyvitamin D in Human Serum -- Radioimmunoassay of Vitamin D Metabolites -- Assays for Vitamin D and its Metabolites -- Radioimmunoassay for Circulating 1,25- and 25,26-Dihydroxycholecaliferols in Man -- Hemisuccinates of Vitamin D3 and of its Metabolites -- Studies on Antisera against Vitamin D Metabolites -- The Measurement of Various Vitamin D Derivatives in Plasma Using High-Pressure Liquid Chromatography -- Assay of 1,25- and 24,25 Dihydoxycholecalciferol in Human Serum - some Technical Considerations -- Radiocompetitive Protein Binding Assays for 25-Hydroxy Vitamin D, 24,25-Dihydroxyvitamin D and 1,25-Dihydroxy-vitamin D in Human Serum -- Steroid Receptors: What do We not Know? -- Vitamin D - Parathyroid Hormone -- Cholecalcifediol suppression of PTH