Systems Medicine

Auteur

Uri Alon is the Abisch-Frenkel Professor of Systems Biology at the Weizmann Institute of Science, Israel. https://www.weizmann.ac.il/mcb/UriAlon/homepage

Texte du rabat

Systems Medicine introduces the topic of physiological circuits, in which cells and organs communicate. It is written in a very accessible style, suitable for anyone with a background in biology, engineering, physics, math, engineering, computer science, chemistry or other subjects.

Contenu

Introduction. 1. The Insulin-Glucose Circuit. 2. Dynamical Compensation, Mutant Resistance, and Type-2 Diabetes. 2.5. Three Laws of Physiology. 3.The Stress Hormone Axis as a Two-Gland Oscillator. 3.5 The Thyroid and its Discontents. 4. Autoimmune Diseases as a Fragility of Mutant Surveillance. 5. Inflammation and Fibrosis as a Bistable System. 6. Basic Facts of Aging. 7. Aging and Saturated Repair. 8. Age-Related Diseases. 9. Periodic Table of Diseases. 10. Epilogue: Simplicity in Systems Medicine.