Translational Methods for PTSD Research

This volume explores the latest experimental techniques in animal models of PTSD and humans affected by PTSD. The methods discussed in this book cover topics such as translational research; addressing sex differences; highlighting the state-of-the-art of biomarker discovery in the development and maintenance of PTSD; and looks at new promising agents to enhance fear extinction retention that may help millions of individuals that suffer from this debilitating disorder worldwide. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Authoritative and thorough, Translational Methods for PTSD Research is a valuable resource that will help researchers understand and learn more about this important disorder.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Contenu
Translational Model of Infant PTSD Induction: Methods for Infant Fear Conditioning.- Periadolescent Social Isolation Effects on Extinction of Conditioned Fear.- Using Virtual Reality to Study Fear and Extinction in Children and Adolescents.- Assessing the Role of Sleep in the Regulation of Emotion in PTSD.- Pavlovian Conditioning and Extinction Methods for Studying the Neurobiology of Fear Learning in PTSD.- Reconciling Translational Disparities between Empirical Approaches to Better Understand PTSD.- An Integrative Model for Endophenotypes Relevant to Posttraumatic Stress Disorder (PTSD): Detailed Methodology for Inescapable Tail Shock Stress (IS) and Juvenile Social Exploration (JSE).- Apolipoprotein E Isoform-Related Translational Measures in PTSD Research.- Stress Immobilization Inducing Fear Extinction Deficits in Male and Female Mice.- 5-HT Neural System Abnormalities in PTSD Model Rats.- Animal Models of PTSD: The Role of Fear Conditioning.- Combining Virtual Reality Exposure Therapy with Non-Invasive Brain Stimulation for the Treatment of Post-Traumatic Stress Disorder and Related Syndromes. A Perspective.- Associating Aversive Task Exposure with Pharmacological Intervention to Model Traumatic Memories in Laboratory Rodents.- Loudness Dependence of Auditory Evoked Potentials (LDAEP): A Promising Pre-Treatment Predictor of Selective Serotonin Reuptake Inhibitor (SSRI) Response.- Preclinical Methods of Neurosteroid-Induced Facilitation of Fear Extinction and Fear Extinction Retention.