Trace Amines

This is the third Proceedings book to arise from biennial conferen ces on the Trace Amines. Since our first meeting in 1983 in Edmonton, Canada, progress has been brisk and, as will be seen from the ensuing pages, it is now possible to include major contributions from inverte brate neurobiologists as well as receptorologists. In the opening ses sion we heard about the distribution of the trace amines-now clear ly a misnomer-in insects and the pharmacological, receptor, and syn aptic characteristics of octopamine and tryptamine as well as the pos sibility of monoamines in general being targets for insecticide discov ery. In mammalian brain the distribution and characterization of the tryptamine receptor has proceeded to the point where two types have been described as well as novel agonists and antagonists, and, for the first time, a binding site for p-tyramine has been described. The com bination of lesions and pharmacological and metabolic manipulations now permits the mapping of trace aminergic pathways, and the rap idly accumulating evidence from releasing drugs, in situ microdialy sis, iontophoresis, and second messenger systems lends credence to the claim that the trace amines possess neuromodulatory functions.

Texte du rabat

This is the third Proceedings book to arise from biennial conferen­ ces on the Trace Amines. Since our first meeting in 1983 in Edmonton, Canada, progress has been brisk and, as will be seen from the ensuing pages, it is now possible to include major contributions from inverte­ brate neurobiologists as well as receptorologists. In the opening ses­ sion we heard about the distribution of the trace amines-now clear­ ly a misnomer-in insects and the pharmacological, receptor, and syn­ aptic characteristics of octopamine and tryptamine as well as the pos­ sibility of monoamines in general being targets for insecticide discov­ ery. In mammalian brain the distribution and characterization of the tryptamine receptor has proceeded to the point where two types have been described as well as novel agonists and antagonists, and, for the first time, a binding site for p-tyramine has been described. The com­ bination of lesions and pharmacological and metabolic manipulations now permits the mapping of trace aminergic pathways, and the rap­ idly accumulating evidence from releasing drugs, in situ microdialy­ sis, iontophoresis, and second messenger systems lends credence to the claim that the trace amines possess neuromodulatory functions.

Contenu
Neurobiology: Invertebrates.- Invited Contributions.- Pharmacological Characteristics of Octopamine-Sensitive Adenylate Cyclase and N-Acetyl Octopamine Transferase in Insects.- Octopamine Receptors on Locust Skeletal Muscle.- The Firefly Light Organ: A Model for a Trace Amine Synapse.- The Regulation of Insect Visceral Muscle by Octopamine.- Monoamines as Targets for Insecticide Discovery.- Submitted Contributions.- N-Acetyl 5-Hydroxytryptamine and N-Acetyl Dopamine in the Cockroach (Periplaneta americana).- Octopaminergic Modulation of Locust Flight Muscle.- Neurobiology: Vertebrates.- Invited Contributions.- Comparison of the Binding of [3H]Tryptamine in Rat Brain with That of Two Ligands for Monoamine Oxidase, PH]MPTP, and [3H]Pargyline.- Tryptamine Turnover: Effects of Drugs.- Trace Amine Binding Sites Identical to Receptors?.- High Affinity Binding of p-Tyramine: A Process in Search of a Function.- Tryptamine, Tryptophan, and Nociception.- Neurobehavioral Aspects of Trace Amine Functions: Affective and Motoric Responses.- Brain Trace Amines: Mapping Studies and Effects of Mesencephalic Lesions.- Dopamine in the Neocortex: A Classical Monoamine Neurotransmitter as a Trace Amine.- Involvement of Newly Synthesized Catecholamines in the Modulation by Trace Amines of the Release of Neurotransmitters.- An Interaction Between ?-Phenylethylamine and Noradrenaline: An Iontophoretic Study in the Rat Cerebral Cortex.- A Contribution to the Neuromodulatory/Neurotransmitter Role of Trace Amines.- Release of Some Endogenous Trace Amines from Rat Striatal Slices in the Presence and Absence of a Monoamine Oxidase Inhibitor.- Phenylethlamine and P-Tyramine in the Extracellular Space of the Rat Brain: Quantification Using a New Radioenzymatic Assay and in situ Microdialysis.- TheEffects of Various Indoles on the Stimulation of Inositol Phosphate Formation in Rat Cortical Slices.- Submitted Contributions.- The Role of Form A Monoamine Oxidase in Head-Twitch Response Induced by para-Hydroxyamphetamine.- Effects of Tryptamine on the Head-Twitch Response Induced by 5-Hydroxytryptamine.- Effects of Tryptamine and 5-HT Microinjected into the Nucleus Accumbens on D-Amphetamine-Induced Locomotor Activity.- Effects of Tryptamine on the Acquisition of a One-Way Active Avoidance Task.- The Effects of p-TA and p-OA on Noradrenergic Mechanisms of the Rat Vas Deferens.- The Use of MAO Inhibitors in Lesion Studies: An Assessment of 'Flooding' in Trace Amine Measurements.- Catecholamine Uptake into Cultured Mouse Astrocytes.- Clinical and Metabolic.- Invited Contributions.- Localization and Inhibition of Monoamine Oxidase Activities.- Prodrugs of ?-Phenylethylamine and Tryptamine: Studies in the Rat.- Alcohol and Biogenic Amine-Derived Alkaloidal Adducts in the Nervous System.- Inhibition of Monoamine Oxidase, Depletion of Lung Biogenic Amines by Cigaret Smoke and the Interaction of Some Components of This Smoke with Trace and Other Amines.- Formation of Cyanomethyl-Derivatives of Biogenic Amines from Cigaret Smoke: Their Synthesis and Identification.- The Tyramine Conjugation Test in Unipolar and Bipolar Depressed Patients: Utility as a Predictor of Treatment Response.- Decreased Tyramine Conjugation in Melancholia: A Trait Marker.- Deuterated Tyramine Challenge Test and Platelet MAO and PST Activities in Normal, Migraine, and Depressive Subjects.- Trace Amine/Catecholamine Relationships: Urinary Rate of Excretion Patterns of Human Subjects Responding to Acute Stress.- Phenylalanine, Phenylethylamine, and Tardive Dyskinesia in Psychiatric Patients.-Metabolism of Tyramine in Subjects Treated with Different Monoamine Oxidase Inhibitors.- Submitted Contributions.- Adrenergic Activities of Octopamine and Synephrine Stereoisomers.- Tyramine-Induced Brain Injury in Phenelzine-Treated Dogs: An Animal Model for Cerebral Edema.- A Quantitative Radionuclide Imaging Technique to Study Cerebral Edema in Dogs with Impaired Monoamine Oxidase.- Urinary Dipeptide with Monoamine Oxidase Inhibitory Properties.- Some Interesting Aspects of Clinical Application of the 24 Hour Human Urine Quantification of PE. A Preliminary Study.