The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Comprehensive assessment of the medical uses of N-Acetyl-Cysteine serves as a single resource for information on this therapeutic

In depth consideration of biological mechanisms puts therapeutic effects in context

Includes a dedicated chapter on safety and special formulations

Auteur
Dr. Richard Frye is the Chief of Neurodevelopmental Disorders at the Barrow Neurological Institute at Phoenix Children's Hospital and Professor of Child Health at the University of Arizona College of Medicine - Phoenix.

Professor Michael Berk is a NHMRC Senior Principal Research Fellow, and is Alfred Deakin Chair of Psychiatry at Deakin University and Barwon Health in Melbourne Australia.

Contenu

1. History of N-acetylcysteine.- Part I. The Basic Science of NAC.- 2. Neurotransmitter Systems: glutamate.- 3. Neurotransmitter Systems: Dopamine.- 4. Oxidative Stress in Psychiatric Disorders.- 5. Mitochondrial Metabolism.- 6. Apoptosis.- 7. Inflammation.- Part II. The Clinical Use of NAC.- 8. Clinical Trials on N-Acetylcysteine.- 9. N-Acetylcysteine in the Poisoned Patient.- 10. The use of NAC as a Chelator for Metal Toxicity.- 11. Application of N-Acetylcysteine in Neurological Disorders.- 12. Application of N-Acetylcysteine in Psychiatric Disorders.- 13. Clinical Treatment of Addictive Disorders with N-Acetylcysteine.- 14. The Clinical Use of N-Acetylcysteine for the Treatment and Protection Against Renal Disease.- 15. Application of N-Acetylcysteine in Pulmonary Disorders.- 16. The Clinical Use of N-Acetylcysteine in Cardiology.- 17. The Clinical Use of N-acetylcysteine in Gastrointestinal Disorders.- 18. The Clinical Use of N-Acetylcysteine in Other Medical Disorders.- 19. The Physiological Effects of N-Acetylcysteine in Clinical Studies.- 20. Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease .- 21. Pharmacology, Formulations and Adverse Effects. <p