The Biology and Pathology of Innate Immunity Mechanisms

In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.

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This book is the proceedings of the Bathsheva de Rothschild Seminar on Innate Immunity, held on October 10-15, 1999, in Zichron Yaakov, Israel. br/ In recent years, scientific attention has focused increasingly on immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body's defense. Identification of pathogens by these mechanisms primarily involves receptors recognizing sugar moieties of various microorganisms. This major new volume describes the recent discoveries in this field, including the implications of the recognition of specific components of the innate immunity arsenal as the main cause of host susceptibility to particular types of infections, and the development of new agents to combat infections using newly identified anti-microbial peptides. There is also coverage of the major themes, such as (i) the role of innate immune responses as a first-line defense against microbial infection and tumor cells; (ii) the cellular and molecular basis of the function of cells and molecules involved in innate immunity; (iii) the role of innate immunity in the immunocompromised host; and (iv) the interactions between innate immunity components and clonal immune response.

Contenu
Pattern Recognition, Receptors and Collectins in Innate Immunity.- Mannose Receptor and Scavenger Receptor: Two Macrophage Pattern Recognition Receptors with Diverse Functions in Tissue Homeostasis and Host Defense.- Complement Receptor 3 (CR3): A Public Transducer of Innate Immunity Signals in Macrophages.- The Role of C-type Lectins in the Innate Immunity Against Pulmonary Pathogens.- Modulation of Nitric Oxide Production by Lung Surfactant in Alveolar Macrophages.- Development of Chimeric Collectins with Enhanced Activity Against Influenza a Virus.- Initial Steps in Streptococcus pneumoniae Interaction with and Pathogenicity to the Host.- Host Cells and Cytokinesin Innate Immunity.- Role of Cytokines in the Maturation and Function of Macrophages.- Mast Cell Modulation of the Innate Immune Response to Enterobacterial Infection.- The Nadph Oxidase Diaphorase Activity in Permeabilized Human Neutrophils and Granulocytic Like PLB-985 Cells.- Activation of Cytosolic Phospholipase A2 by Opsonized Zymosan in Human Neutrophils Requires Both ERK and p38 Map-Kinase.- Cytosolic Phospholipase A2 is Required for the Activation of the Nadph Oxidase Associated H+ Channel in Phagocyte-Like Cells.- The Role of NK Cells in Innate Immunity.- Similarities and Dissimilarities Between Humans and Mice Looking at Adhesion Molecules Defects.- The Role of Dendritic Cells at the Early Stages of Leishmania Infection.- DNA-Based Vaccines: Role of Dendritic Cells in Antigen Presentation.- Distinct Patterns of IL-L and IL-L Organ Distribution-A Possible Basis for Organ Mechanisms of Innate Immunity.- Antimicrobial Peptides.- Structure and Biology of Cathelicidins.- Structure Activity Relationship Study of Polymyxin B Nonapeptide.- Innate Immunity in the Compromised Host.- The Clinical Significance of Neutrophil Dysfunction.- Clinical Significance of Functional Aberrations in Macrophage and NK Cells, in Type-1 Cytokines and in Lectin-Binding Molecules.- Klebsiella Infections in the Immunocompromised Host.- Innate Immunity Components in Cancer.- Macrophage-Recognized Molecules of Apoptotic Cells are Expressed at Higher Levels in AKR Lymphoma of Aged as Compared to Young Mice.- Sensitivity to Macrophages Decreases with Tumor Progression in the AKR Lymphoma.- Opposing Effects of IL-1? and IL-1? on Malignancy Patterns.- Abstracts.