Synthesis and Applications of Isotopically-Labelled Compounds

Auteur
David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtree's catalyst in HIE in 1995.

Texte du rabat

Synthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics reviews recent advances in the field of tritium, carbon-14, and stable isotope compound synthesis along with their analysis. The emerging field of the development of deuterated pharmaceuticals is also discussed, along with the application of isotopically labelled compounds in drug metabolism studies. There book presents a comprehensive guide to the field for the community, as well as newcomers, interested parties, or collaborators who need to be able to communicate with labeling groups. This book fills this gap and provides a "one-stop shop" by having a comprehensive review of recent developments. Sections cover analytical chemistry in depth and include new sections on methods of stable isotope analysis. Analytical chemistry aspects of these specific areas are also covered.

Contenu

1. General Introduction
   
   2. Recent advances in tritium chemistry
   3. Recent advances in carbon-14 chemistry
   4. Recent advances in the chemistry of PET and SPECT isotopes
   5. Recent advances in the chemistry of stable isotopes
   6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
   7. Non pharmaceutical applications of labelled compounds
   8. Emerging new fields in the chemistry of isotopes and their application
   9. Deuterated APIs
   10. Recent advances in the analysis of isotopically labelled compounds
   11. Radiolabeling of large molecules
   12. Summary and outlook