Growth, Cancer, and the Cell Cycle

Cell growth, one of the most fundamental of biological processes, has long been among the least understood. On April 24-28, 1984 sci entists convened from around the world in Canada's Banff National Park for The International Cell Cycle Society's 10th Conference. Their purpose was to evaluate recent developments in the field of cell prolif eration and to explore the interrelationship between cell growth, de velopment, and differentiation, and proliferative diseases such as can cer. Growth, Cancer, and the Cell Cycle collects those conference papers that present the most recent advances in this field. The first section of the book is Gene Expression and Development During Growth. It examines the structure and function of chromatin, DNA unwinding proteins, and nonhistone nuclear proteins, then ex plores transcriptional, translational, and post-translational regulation during the cell cycle and the interrelationship and coordinate regula tion of cell growth, differentiation, and gene expression. The second section, Growth Activation and Dormancy, focuses upon the events that occur during the transition between active cell growth and proliferative quiescence. The role of DNA strand breaks, protein kinase activity, growth regulatory factors, and the cytoskeleton are examined. Section three discusses The Topology of the Cell Cycle. It reviews genetic approaches for determining the sequence of events and cau sality relationships that comprise and coordinate the many separate processes involved in cell cycle progression and describes the use of multipara meter flow cytometry to characterize the mammalian cell cy cle and intracellular metabolic and transitional growth states.

Contenu
I. Gene Expression and Development During Growth.- Structures Inherent to Chromatin Active in Transcription and Replication.- Chromatin Changes in Skeletal Muscle Cells During the Fusion to Myotubes.- A Eucaryotic Protein with Helix Destabilizing Activity and its Homology to LDH.- Role of Nonhistone Protein Phosphorylation in the Regulation of Mitosis in Mammalian Cells.- Nonhistone Proteins, Free Radical Defenses and Acceleration of Spherulation in Physarum.- Coordinate and Non-Coordinate Regulation of Histone mRNAs During Myoblast Growth and Differentiation.- The Receptor Binding of Insulin and Poly(ADP-Ribose) Synthesis During the Cell Cycle.- A Novel Method of Translation in Fibroin.- Tubulin and Actin Gene Expression During the Cell Cycle.- II. Growth Activation and Dormancy.- Regulation of Nuclear and Mitochondrial RNA Production After Serum Stimulation of Quiescent Mouse Cells.- A Decrease in the Steady Level of DNA Strand Breaks as a Factor in the Regulation of Lymphocyte Proliferation.- 70 K Dalton Protein Synthesis and Heat Sensitivity of Chromatin Structure: Dependence on Cell Cycle.- Involvement of Protein Kinases in Mitotic-Specific Events.- Protein Kinase Activity in Lymphocytes; Effects of Concanavalin A and A Phorbol Ester.- Effect of Gossypol on DNA Synthesis in Mammalian Cells.- Growth Activation in Adult Rat Hepatocytes.- Isolation and Characterization of a Growth Regulatory Factor from 3T3 Cells.- Changes in Adhesion, Nuclear Anchorage, and Cytoskeleton During Giant Cell Formation.- III. Topology of the Cell Cycle.- The G1 Cell Cycle Interval in Yeasts.- Coordination of Growth With Cell Division in Yeasts.- Changed Division Response Mutants Function as Allosuppressors.- Molecular and Cell Biology of Cell Cycle Progression Revealed by Mammalian CellsTemperature-Sensitive in DNA Synthesis.- Metabolic and Kinetic Compartments of the Cell Cycle Distinguished by Multiparameter Flow Cytometry.- IV. Neoplastic Transformation.- Cancer Cell Heterogeneity in Resistance to Mechanical Trauma in the Microcirculation as Part of Metastasis.- Expression of an Activator RNA Hybridizable to the SV40 Promotor Correlates with the Transformed Phenotype of Mouse and Human Cells.- Gastrointestinal Cells: Growth Factors, Transformation, and Malignancy.- A New Technique for Diagnosing Cancer by Inspecting Blood Serum.- Cytokinetics of Heteroploid Tumor Subpopulations by Combined Autoradiographic Imaging and Feulgen Densitometry.- Cell Growth, Tissue Neogenesis, and Neoplastic Transformation.