Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices

This book chronicles the role of advanced nanomaterials and surface engineering technologies in the development of point-of-care biosensors for health and environmental monitoring. All aspects of nanomaterial synthesis and characterization, functionalization methods, sensing surface engineering, signal amplification strategies, use of innovative technologies to enhance sensor efficiency and performances, and innovative applications of nanobiosensors to tackle real-life problems are discussed in this book with a focus on optical and electrochemical based sensing. It also covers the detection of infectious diseases and various disease biomarkers, smartphone-based biosensing, and portable diagnostics module developments with a discussion on the working mechanisms of these devices in various domains. The book also illustrates the recent trends in biosensing, and an overview of the challenges and probable solutions for the translation of biosensors from laboratory prototypes to commercial success.

Reviews surface engineering technologies for bioanalytical devices Discusses challenges and opportunities of commercial viability of biosensors Presents lab-on-a-chip devices for point-of-care Medical Diagnostics

Auteur

Dr. Buddhadev Purohit is currently working at Department of Biotechnology and Biomedicine (DTU Bioengineering), Technical University of Denmark. He obtained his Master's degree in Life Sciences from Sambalpur University, and pursued his Ph.D. at the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India. His research focuses on designing of novel electrochemical and optical biosensing platforms. He is also involved in development of microfluidics systems, smartphone-based biosensors, and portable, low-cost diagnostic devices.

Prof. Pranjal Chandra is an Associate Professor at the School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, India. He earned his Ph.D. from Pusan National University, South Korea and did post-doctoral training at Technion-Israel Institute of Technology, Israel. His research focus is highly interdisciplinary, spanning a wide range in biotechnology,nanobiosensors, material engineering, and nanomedicine. He has designed several commercially viable biosensing prototypes that can be operated for onsite analysis for biomedical diagnostics. He is an associate editor / editorial board member of various international journals, including Scientific Reports, Sensors International, Frontiers in Bioengineering and Biotechnology, Molecules, Frontiers in Sensors, and Green Analytical Chemistry. He is an expert member/reviewer of various national and international funding agencies. He has also been appointed as Advisor for the Biomedical Sensors Domain and Sensor Networks Systems at the Institution of Engineering and Technology (IET), Michael Faraday House, LONDON, United Kingdom. Prof. Chandra has authored over 140 high-impact publications, including research/review papers and invited book chapters and published 15 books on biosensors/medical diagnostics / material engineering. He has guided 5 Ph.D. and currently supervising 8 Ph.D. students. Prof. Chandra received many prestigious awards, coveted honors, and fellowships, such as Fellow of the Indian Chemical Society, Shakuntala Amirchand Award 2020 by the Indian Council Of Medical Research, NASI-Prof. B.K. Bachhawat Memorial Young Scientist Lecture Award (2022); FSSAI Eat Right Award-2022 (Government of India); DST Ramanujan fellowship (Government of India); Early Career Research Award (ECRA) (DST, Government of India); BK -21 and NRF fellowship, South Korea; Technion Post-Doctoral Fellowship, Israel; Nano Molecular Society India Young Scientist Award; Biotech Research Society India Young Scientist Award; Young Engineers Award 2018; Highly Cited Corresponding authors in The Royal Society of Chemistry (RSC), Cambridge, London; Top 10% cited article in the General Chemistry Section RSC Journal, Cambridge, London, Gandhian Young Technology Innovation Award (GYTI) 2020, etc. Dr. Chandra is also listed among the world's top 2% scientists in 2020 and 2021 by Stanford University, USA.

Contenu

Chapter 1_ Advanced surface engineering strategies for point-of-care devices.- Chapter 2_ Nanomaterial functionalization strategies for point-of-care devices.- Chapter 3_ Advances in two- and three-dimensional nanomaterials for biosensor development.- Chapter 4_ Carbon based nanomaterials and their functionalization strategies for biosensing.- Chapter 5_ Magnetic nanoparticles based biosensing strategies for clinical analysis.- Chapter 6_ Surface Engineered Nanobiosensors for Disease Biomarker Identification.- Chapter 7_ Nano-bio-analytical systems for detection of emerging infectious diseases.- Chapter 8_ Bioanalytical devices for whole cell and bacteria detection.- Chapter 9_ Sensing surface development for volatile organic compound detection.- Chapter 10_ Recent trends in enzyme-based sensing devices for clinical analysis.- Chapter 11_ Paper based sensing devices for clinical and environmental monitoring.- Chapter 12_ Smartphone interface and wearable biosensors for onsite diagnosis.- Chapter 13_ Designing aptamers based optical bioanalytical systems.- Chapter 14_ Lab-on-a-chip based multiple analytes detection system.- Chapter 15_ Commercialization of nanobiosensors: Challenges and opportunities.

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