Fundamentals of Veterinary Clinical Pathology

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The editors Steven L. Stockham, DVM, MS, Diplomate, American College of Veterinary Pathologists (Clinical Pathology), now deceased, was a Professor in the Department of Diagnostic Medicine/Pathobiology and Director of the Clinical Pathology Laboratory, College of Veterinary Medicine, Kansas State University, USA. Michael A. Scott, DVM, PhD, Diplomate, American College of Veterinary Pathologists (Clinical Pathology), is an Associate Professor Emeritus in the Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, USA.

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Provides the information needed to interpret clinical laboratory assays of domestic mammals Fundamentals of Veterinary Clinical Pathology, Third Edition presents thoroughly updated and detailed information to promote appropriate clinical laboratory testing and interpretation of test results for common domestic mammals. Presented in an easy-to-use outline format complemented by many relevant tables and illustrations, the book is now in full color. This evidence-based guide synthesizes the laboratory principles, physiology, assays, analytical concepts, pathophysiologic states, and pathophysiologic processes relevant to detecting, evaluating, and understanding disorders in dogs, cats, horses, cattle, and camelids. Content additions include two entirely new chapters on synovial and cerebrospinal fluid analysis, as well as expanded sections on blood typing and crossmatching, viscoelastic testing, protein electrophoresis, positive acute-phase proteins, mixed acid-base disorders, vitamin D analysis, analytical and biological variation, blood smear evaluation, and more. New clinical tests and methods, useful data patterns, and additional disorders and pathologic processes are integrated throughout. Providing a conceptual understanding applicable to many species and serving as a valuable clinical reference, Fundamentals of Veterinary Clinical Pathology: Uses consistent terminology and chapter organization featuring separate sections for physiologic concepts, analytical methods, and interpretation of resultsProvides pathophysiologic explanations of laboratory abnormalitiesAllows easy access to information on disorders and conditions, grouping them by common mechanisms or processes and ordering them in parallel across interpretive tables and textFeatures a wealth of high-quality illustrations and photomicrographs throughout the textIncludes extensive referencing to support statements and provide direction for further reading Fundamentals of Veterinary Clinical Pathology, Third Edition is an excellent textbook for veterinary students taking clinical pathology courses, as well as a valuable resource for clinical and anatomic pathology residents, medicine and surgery residents, and practicing veterinarians.

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Notes on Contributors ix

Preface xi

Acknowledgments xiii

About the Companion Website xv

1 Analytical and Diagnostic Concepts: Getting it Right 1
Kristen R. Friedrichs, Michael A. Scott, and Steven L. Stockham

2 Leukocytes 61
Michael A. Scott and Steven L. Stockham

3 Erythrocytes 135
Michael A. Scott and Steven L. Stockham

4 Platelets 275
Michael A. Scott and Steven L. Stockham

5 Hemostasis 319
Michael A. Scott and Steven L. Stockham

6 Bone Marrow and Lymph Nodes 401
Michael A. Scott and Steven L. Stockham

7 Proteins 469
Kristen R. Friedrichs, Michael A. Scott, and Steven L. Stockham

8 Urinary System 537
Michael A. Scott and Steven L. Stockham

9 Monovalent Electrolytes and Osmolality 643
Steven L. Stockham and Michael A. Scott

10 Blood Gases, Blood pH, and Strong-Ion Difference 729
Steven L. Stockham and Michael A. Scott Copyrighted Material

11 Calcium, Phosphorus, Magnesium, and their Regulatory Hormones 781
Michael A. Scott and Steven L. Stockham

12 Selected Enzyme Activities and Enzymatic Proteins 845
Michael A. Scott, Michael M. Fry, and Steven L. Stockham

13 Hepatobiliary Function 887
Michael A. Scott, Michael M. Fry, and Steven L. Stockham

14 Glucose, Ketoamines, and Related Regulatory Hormones (Insulin, Glucagon, Growth Hormone, and Insulin-Like Growth Factors-1 and 2) 923
Michael A. Scott and Steven L. Stockham

15 Exocrine Pancreatic and Intestinal Functions 969
Michael A. Scott, Michael M. Fry, and Steven L. Stockham

16 Lipids 999
Kristen R. Friedrichs, Michael A. Scott, and Steven L. Stockham

17 Thyroid Function 1031
Michael A. Scott and Steven L. Stockham

18 Adrenal Gland 1059
Michael A. Scott and Steven L. Stockham

19 Peritoneal, Pleural, and Pericardial Effusions 1103
Michael A. Scott and Steven L. Stockham

20 Synovial Fluid 1163
Michael M. Fry, Michael A. Scott, and Steven L. Stockham

21 Cerebrospinal Fluid 1189
Michael A. Scott and Steven L. Stockham

Appendix A: The Complete Blood Count and Blood Smear Evaluation 1221

Index 1231