Stem Cell Engineering

This book describes a global assessment of stem cell engineering research, achieved through site visits by a panel of experts to leading institutes, followed by dedicated workshops. The assessment made clear that engineers and the engineering approach with its quantitative, system-based thinking can contribute much to the progress of stem cell research and development. The increased need for complex computational models and new, innovative technologies, such as high-throughput screening techniques, organ-on-a-chip models and in vitro tumor models require an increasing involvement of engineers and physical scientists. Additionally, this book will show that although the US is still in a leadership position in stem cell engineering, Asian countries such as Japan, China and Korea, as well as European countries like the UK, Germany, Sweden and the Netherlands are rapidly expanding their investments in the field. Strategic partnerships between countries could lead to major advances of the field and scalable expansion and differentiation of stem cells. This study was funded by the National Science Foundation (NSF), the National Institutes of Health (NIH) and the National Institute of Standards and Technology (NIST).

Provides an overview of the worldwide status and trends in stem cell engineering Describes how the US need to form strategic partnerships with other countries so as to leverage the existing and emerging strength outside of the US Confirms the need for an increasing involvement of engineers in the field of stem cells and related technologies Describes how computational models will be increasingly important to understand complex biological systems Provides guidance to policy makers and funding agencies on future research directions and required investments Includes supplementary material: sn.pub/extras

Contenu
Preface.- Executive Summary.- Introduction.- Physical and Engineering Principles in Stem Cell Research.- High-throughput Screening, Microfluidics, Biosensors and Real-time Phenotyping.- Computational Modeling and Stem Cell Engineering.- Stem Cell Bioprocessing and Biomanufacturing.- Appendix A. Delegation Biographies.- Appendix B. Site Visit Reports.- Appendix C. 'Virtual' Site Visit Reports.- Appendix D. Glossary of Abbreviations and Acronyms.