St. Andrews, Scotland, September 21 24, 1982

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Frontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds / Huennekens, F.M. / Suresh, M.R. / Grimshaw, C.E. / Jacobsen, D.W. / Quadros, E.T. / Vitols, .S. / Henderson, G.B. -- Chemical Aspects (1) -- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products / Taylor, Edward C. -- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins / Bailey, Steven W. / Ayling, June E. -- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] / Armarego, Wilfred L.F. / Waring, Paul -- Some Simple s-Triazolopteridines / Brown, Desmond J. / Shinozuka, Kazuo -- Linear Tricyclic Analogs of Pteridines / Pendergast, William / Chan, Joseph H. -- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis / Boyle, Peter / Lockhart, Ronan -- Syntheses of some Blocked 7,8-Dihydropteridines / Cameron, Bobert C. / Lyall, William J.S. / Nicholson, Sidney H. / Bobinson, David H. / Suckling, Colin J. / Wood, Hamish C.S. -- Synthesis of Chiral Reduced Pteridine Coenzymes / Doyle, Paul M. / Szakolcai, Akos / Young, Douglas W. -- Report on Discussions / Benkovic, S. J. -- Chemical Aspects (2) -- Reactivity of Pteridines / Pfleiderer, Wolfgang / Baur, Ralph / Bartke, Michael / Lut, Hermann -- Synthesis and Antitumor Activity of 10-Deazaminopterins / DeGraw, J. I. / Brown, V. H. / Tagawa, H. / Kisliuk, R. L. / Gaumont, Y. / Sirotnak, F. M. -- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin / Taylor, Edward C. / Tseng, Chi-Ping / Harrington, Peter J. / Beardsley, G. Peter / Rosowsky, Andrew / Wick, Michael -- The Nor-Analogues of Folic Acid / Nair, M.G. / Rozmyslovicz, Mary K. / Kisliuk, R.L. / Gaumont, Y. / Sirotnak, F.M. -- Report on Discussions / Roth, B. -- Neurochemical and Clinical Aspects -- Metabolism of Pteridine Cofactors in Neurochemistry / Nichol, Charles A. / Viveros, O. Humberto / Duch, David S. / Abou-Donia, Martha M. / Smith, Gary K. -- Pteridines in Cancer and Other Diseases / Rokos, Katharina / Rokos, Hartmut / Frisius, Hildegard / Hüfner, Michael -- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing / Dhondt, Jean-Louis / Herlin, Christophe / Bonneterre, Jacques / Vie, M. Claude / Lefebvre, Jean / Demaille, Alain -- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE / Blair, J.A. / Whitburn, S.B. / Pheasant, .E. / Leeming, R.J. / Morar, C. / Al-Beir, A. -- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate / Kapatos, Gregory / Kaufman, Seymour -- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis / Levine, Robert A. / Lovenberg, Walter / Niederwieser, A. / Leimbacher, W. / Redweik, U. / Staudenmann, W. / Curtius, H.-Ch. -- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia / Niederwieser, A. / Staudenmann, W. / Wang, M. / Curtius, H.-Ch. / Atarés, M. / Cardesa-Garcia, J. -- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers / Erbe, Richard W. / Wang, Jin-Chen C. -- Report on Discussions / Cotton, R. G. H. -- Enzymology -- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase / Roberts, Gordon C.K. -- Catalytic Site of Dihydrofolate Reductase / Blakley, Raymond L. / Cocco, Lennie / Montgomery, John A. / Temple, Carroll / Roth, Barbara / Daluge, Susan / London, Robert E. -- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase / Freisheim, J.H. / Susten, S. S. / Delcamp, T. J. / Rosowsky, A. / Wright, J. E. / Kempton, R. J. / Blankenship, D. T. / Smith, P. L. / Kumar, A .A. -- Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver / Lewis, Garry P. / Rowe, Peter B. -- Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine / Vanoni, Maria A. / Daubner, S. Colette / Ballou, David P. / Matthews, Rowena G. -- Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis / Stokstad, E.L.R. / Chan, M.M-S. / Watson, J.E. -- The Mechanism of Action of the Transformylase Enzymes / Smith, Gary K. / Mueller, W. Thomas / Benkovic, Patricia A. / Slieker, Lawrence J. / DeBrosse, Charles W. / Benkovic, Stephen J. -- Folypolyglutamate Synthesis in Neurospora Crassa / Cossins, E.A. / Chan, P. Y. -- Report on Discussions / Baccanari, D. P. / Kuyper, L. F. -- Clinical Aspects: Cancer -- Folates and Cancer Chemotherapy / Bertino, J.R. / McGuire, J. J. -- Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells / Scott, J. M. / Molloy, A. / Smithwick, A. / McGing, P. / Weir, D. G. -- A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells / Rothenberg, Sheldon / Iqbal, M. Perwaiz -- Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases / ieger, Irmgard / Armarego, Wilfred L. F. / Fink, Michael -- Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates / Cody, Vivian / DeJarnette, Elaine / Zakrzewski, Sigmund F. -- Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations / Potterton, E. A. / Geddes, A. J. / North, A. C. T. -- Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells / Galivan, John / Balinska, Malgorzata -- Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools / Bestwick, Richard K. / Moffett, Ginnie L. / Spiro, Craig / Mathews, Christopher K. -- Report on Discussions / Whiteley, J. M. -- Bioorganic Chemistry and Enzymology -- Chemical Mechanisms in the Action of Pteridine Coenzymes / Young, Douglas W. -- Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin / Parniak, Michael / Kaufman, Seymour -- p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase / Webber, Stephanie / Whiteley, John M. -- Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase / Jongejan, J. A. / Mager, H. I. X. / Berends, W. -- Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases / Ayling, June E. / Bailey, Steven W. -- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates / Lazarus, Robert A. / DeBrosse, Charles W. / Benkovic, Stephen J. -- Properties of Thymidylate Synthase from Streptococcus Faecium / Kisliuk, R. L. / Rao, . N. / Gaumont, Y. / Deschenes, R. / Vestal, K. / Karasik, M. / Maley, G. F. / Nair, M. G. / Baugh, C. M. -- Cloning the Gene for Eukaryotic C1-THF Synthase / Stäben, Chuck / Rabinowitz, Jesse C. -- Report on Discussions / Armarego, W. L. F. -- Biochemistry and Biology -- The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate / Wiederrecht, Gregory J. / Paton, Duncan R. / Brown, Gene M. -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis / Hearl, W. G. / Dorsett, D. / Jacobson, K. Bruce -- The Common Precursor of Sepiapterin and Drosop…