Photonic Sensors for Detection of VOC Biomarkers

Auteur
S. Krishnaswamy: Prof. Krishnaswamy has been a member of the faculty of mechanical engineering at Northwestern University since 1990. He received his MS and PhD degrees in aeronautics from California Institute of Technology in 1984 and 1989, respectively. Currently, he is the director of the Center for
Smart Structures and Materials at Northwestern University. He has been actively involved in the areas of nondestructive materials characterization, optical metrology, structural health management, and fiber-optic and 3D printed photonic sensors. He is a fellow of SPIE and ASME. Akhilesh Kumar Pathak: Dr. Pathak obtained his Ph.D. degree from the Indian Institute of Technology (Indian School of Mines), India in 2019. During his Ph.D. he was awarded a prestigious EM Leaders fellowship in 2017 to conduct part of his Ph.D. from the City University of London, United Kingdom. In 2020 he was granted C2F post-doctoral fellowship to conduct his two years post-doctoral research at
Chulalongkorn University, Thailand. Currently, he is working as a post-doctoral scholar at Northwestern University, USA under the supervision of Prof. S. Krishnaswamy. He is a Senior Member of IEEE and OPTICA and also serving as an editorial board member for the Journal of Sensors. He has published
more than 30 International Journals, conferences, and book chapters and being cited by more than 591 times with an h-index of 16. He has also reviewed more than 300 journals and edited more than 30 articles for the Journal of Sensors, Photonics, Frontier in Photonics, and Frontier in Physics. His research interest includes optical fiber modeling using the full vectorial finite element method (FV-FEM), femtosecond direct laser-writing, 3D printing using two-photon polymerization, synthesis and
controlled growth of nanoparticles, hydrogels, and specialized optically active material for various sensing applications.C. Viphavakit: Charusluk Viphavakit was born in Bangkok, Thailand. She received the Bachelor's degree in Nanoelectronic Engineering from Chulalongkorn University, Thailand, in 2010, the Master's degree in nanotechnology from the Asian Institute of Technology, Thailand, in 2012, and the Ph.D. degree from Frederick University, Cyprus, with ERASMUN MUNDUS scholarship in 2015 and from City, University of London, UK in 2018. She was a Postdoctoral Researcher in Optical Fibre Research Centre, University of
Limerick, Ireland, through Irish Research Council Fellowship for two years. During her postdoctoral career in 2016, she received Harvard Medical School Scholarships and University of Limerick Graduate Entry Medical School funding to enrol in Global Clinical Scholars Research Training Program (GCSRT) 2016-2017 from Harvard Medical School (HMS), Boston, MA, USA, for advanced training and conducting of clinical research. She is a Senior Member of IEEE and IEEE Photonics Society. She is also a member of OPTICA and SPIE. She is currently a full-time Assistant professor, and head of Nano?Engineering program at the International School of Engineering, Chulalongkorn University. She is in the editorial board of the Engineering Journal. Her research interests include optical waveguide and optical fiber sensor for biomedical applications.

Texte du rabat
VOCs available in exhaled human breath are the products of metabolic activity in the body and, therefore, any changes in their control level can be utilized to diagnose specific diseases. More than 1000 VOCs have been identified in exhaled human breath along with the respiratory droplets which provide rich information on overall health conditions. This book cover the introductory information on VOCs, their source in the human body, associated diseases, potential sensing materials used for selective detection, and the advancement in their sensing technology. These VOCs offer great potential as a biomarker for a disease that can be sampled non-invasively from exhaled breath with breath biopsy. However, it is still a great challenge to develop a rapid responsive, highly selective, and sensitive VOC-sensing system. This book analyzes all the challenges and their possible solutions that can be used to achieve target-specific detection and real-time monitoring of the VOC molecules in the exhaled breath. It also covers a detailed discussion of all the sensing materials developed for selective and sensitive detection of VOC molecules and their integration with photonic devices in order to develop miniature technology. It covers various miniature sensing systems that are being exploited in VOC sensing such as interferometer, Bragg grating, microstructured fiber, 3D printed optical sensing systems, etc. The book will also provide an overview of the FEM technique and computation methods used to optimize the optical sensing devices before their practical realization. Photonic sensors for detection of VOC biomarkers aims to provide comprehensive information to early career professionals and boost their existing knowledge in the area of Chemistry and Biomedical Engineering.

Contenu

1. Introduction to volatile organic compounds
   
   2. Source of VOCs in human breath
   3. Disease related biomarkers in exhaled breath
   4. Photonic devices and their role in VOC monitoring
   5. Sensing devices of VOCs: design and simulation
   6. Advances in the Selection of VOC Sensing Materials
   7. Interferometer Techniques for Breath Monitoring
   8. Fiber grating for VOC detection
   9. Microstructured optical fiber (MOF) VOC sensors
   10. Advances, Case Studies and Best Practices