Smart Organ-on-Chip Devices

Auteur
Professor Balbino is coordinator of the Graduate Program in Nanotechnology Engineering, at the Alberto Luiz Coimbra Institute for Postgraduate Studies and Research in Engineering, Latin America's largest center for research and education in engineering, located at the Federal University of Rio de Janeiro. He's a chemical engineer and holds a PhD and a master's in chemical engineering, whose research has focused on the development of microfluidic processes to produce nanostructured gene delivery systems. During his doctorate, he did a research internship at the National Institute of Standards and Technology, in the US, working on the microfabrication of different devices for biomedical applications. He did a postdoc at the Mechanical Engineering Department at PUC in Rio de Janeiro. His work focuses on the development of microfluidic chips as technological solutions for different applications of nanotechnology engineering. He's also been working with organ-on-chip devices for drug development, disease modeling and tissue engineering. Dr. Bartolo is Chair Professor on Advanced Manufacturing at the School of Mechanical, Aerospace and Civil Engineering (MACE), University of Manchester (UK); Visiting Professor at Nanyang University (Singapore), Professor of Biomaterials at the University of Havana (Cuba); Collaborator Professor of both the Advanced Manufacturing Group at the Tecnologico de Monterrey (Mexico) and The Research Centre for Architecture, Urbanism and Design a Centre of Excellence of the Portuguese Foundation for Science and Technology based at the University of Lisbon (Portugal). At the School of MACE, he is the Head of the Manufacturing Group. At the University of Manchester, he is the industry 4.0 Academic Lead, member of the Management Board of the EPSRC & MRC Centre for Doctoral Training (CDT) in Regenerative Medicine and theme leader of the Industry 4.0” Societal Challenge area within the Digital Futures. Since 2002, Dr. Bartolo has been engaged in 90+ research projects funded by the UK Engineering and Physical Sciences Research Council, Innovate UK, Bill and Melinda Gates Foundation, the Royal Society, the Portuguese Foundation for Science and Technology, the Portuguese Agency for Innovation, the European Commission, and Industry.Ms. Letícia Charelli has a BSc and an MSc in Biotechnology with emphasis on biofabrication, 3D cell culture, and microfluidics. She is currently working with industry players to optimize protocols for regenerative medicine, drug development, and disease modeling. Letícia uses her extensive knowledge to translate the research data from the bench to the bedside as a functional product. Her expertise in microfluidics (e.g., organ-on-chip platforms) have resulted in several international articles, partnership with industries as well as lecturing for undergraduate, graduate, and professionals of several fields.

Texte du rabat
Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology. The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry.

Contenu

Section 1 - Microfluidics and Organ-on-chip Technologies

1. Organotypic on-chip models: Bridging the gap between traditional in vitro culture and animal testing
2. Microfabrication processes for the manufacturing of smart organ-on-chip devices
3. Bioprinted organ-on-a-chip: A strategy to achieve humanized in vitro models
4. Disease modeling and developmental biology through microfluidic channels

Section 2 - Stimuli Active Organotypic-on-chip Devices

5. Pathological conditions of mechanobiology: How microfluidic devices are helping to understand the role of mechano-stimuli in oncology
6. Mechanically active organotypic-on-chip devices for dynamic cell culture
7. Sensors within microfluidic chips: optofluidics to explore in vitro organoid behavior
8. Photothermal and magnetic cell stimuli cause by nanoparticles inside organ-on-chip platforms

Section 3 - Microphysiological Case Studies

9. Brain-on-chip microplatforms for precision medicine, disease modeling, and developmental biology
10. Dynamic mircophysiological systems to access sickle cell disease - a case study for disease modeling
11. Engineered microfluidic systems for mimicking signaling cascades in continuous-flow cell culture
12. Mechanically active heart-on-a-chip: toward a reliable heart beating study model
13. Remaining challenges: Are we close to a physiologically representative in vitro model for clinical deployment?