The Song of the Cell

From the author of The Emperor of All Maladies , winner of the Pulitzer Prize, and The Gene , a #1 New York Times bestseller, comes his most spectacular book yet, about the fundamental unit of life. Rich with Mukherjee''s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer''s exploration of what it means to be human. In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek look down their hand-made microscopes. What they see introduces a radical concept that sweeps through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It is the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves - hearts, blood, brains - are built from these compartments. Hooke christens them " cells" . The discovery of cells -and the reframing of the human body as a cellular ecosystem - announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer''s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia - all could be re-conceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. In The Song of the Cell , Mukherjee tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. He seduces readers with writing so vivid, lucid and suspenseful that complex science becomes thrilling. Told in six parts, laced with Mukherjee''s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate - a masterpiece. ...

Auteur

Siddhartha Mukherjee is the author of The Gene: An Intimate History, a #1 New York Times bestseller, The Emperor of All Maladies: A Biography of Cancer, winner of the 2011 Pulitzer Prize in general nonfiction, and The Laws of Medicine. He is the editor of Best Science Writing 2013. Mukherjee is an Associate professor of medicine at Columbia University and a cancer physician and researcher. A Rhodes scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. He has published articles in many journals, including Nature, The New England Journal of Medicine, Cell, The New York Times and The New Yorker. He lives in New York with his wife and daughters. Visit his website at: SiddharthaMukherjee.com

Texte du rabat

Longlisted for the Baillie Gifford Prize 2023A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR 2022From the prize-winning author of The Emperor of All Maladies, The Song of the Cell tells the vivid, thrilling and suspenseful story of the fundamental unit of life. In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look down their hand-made microscopes. What they see introduces a radical concept that alters both biology and medicine forever. It is the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves, are built from these compartments. Hooke christens them 'cells'. The discovery of cells announced the birth of a new kind of medicine. A hip fracture, a cardiac arrest, Alzheimer's, AIDS, lung cancer - all could be re-conceived as the results of cells, or a cellular ecosystem, functioning abnormally. And all could be treated by therapeutic manipulations of cells. This revolution in cell biology is still in progress: it represents one of the most significant advances in science and medicine. Both panoramic and intimate, this is Siddhartha Mukherjee's most spectacular book yet.

Résumé

Longlisted for the Baillie Gifford Prize 2023

A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR 2022

From the prize-winning author of The Emperor of All Maladies, The Song of the Cell tells the vivid, thrilling and suspenseful story of the fundamental unit of life.

In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look down their hand-made microscopes. What they see introduces a radical concept that alters both biology and medicine forever. It is the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves, are built from these compartments. Hooke christens them 'cells'.

The discovery of cells announced the birth of a new kind of medicine. A hip fracture, a cardiac arrest, Alzheimer's, AIDS, lung cancer - all could be re-conceived as the results of cells, or a cellular ecosystem, functioning abnormally. And all could be treated by therapeutic manipulations of cells. This revolution in cell biology is still in progress: it represents one of the most significant advances in science and medicine.

Both panoramic and intimate, this is Siddhartha Mukherjee's most spectacular book yet.