Cancer as a Metabolic Disease

Informationen zum Autor THOMAS N. SEYFRIED! PhD! has taught and conducted research in the fields of neurogenetics! neurochemistry! and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism! Journal of Lipid Research! Neurochemical Research! and ASN Neuro. Klappentext A groundbreaking new approach to understanding! preventing! and treating cancerSupported by evidence from more than 1!000 scientific and clinical studies! this groundbreaking book demonstrates that cancer is a metabolic disease and! more importantly! that it can be more effectively managed and prevented when it is recognized as such. Moreover! the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book! he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease! including inflammation! vascularization! cell death! drug resistance! and genomic instability. In addition! the book explores: Origin of metastasis New treatment strategies that target tumor cell energy metabolism! including the ketogenic diet More effective prevention strategies in light of the metabolic origin of cancer Case studies and perspectives from the point of view of physicians! patients! and caregiversThroughout the book! tables! figures! and graphs summarize key information and clarify complex concepts. In addition! the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease! the book sets readers on a new! more promising path to understanding the origins of cancer and developing new! more effective strategies to treat and prevent it. Zusammenfassung The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. Inhaltsverzeichnis 76608137 ...

Auteur

THOMAS N. SEYFRIED, PhD, has taught and conducted research in the fields of neurogenetics, neurochemistry, and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism, Journal of Lipid Research, Neurochemical Research, and ASN Neuro.

Texte du rabat

A groundbreaking new approach to understanding, preventing, and treating cancer

Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.

Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores:

• Origin of metastasis
• New treatment strategies that target tumor cell energy metabolism, including the ketogenic diet
• More effective prevention strategies in light of the metabolic origin of cancer
• Case studies and perspectives from the point of view of physicians, patients, and caregivers
  Throughout the book, tables, figures, and graphs summarize key information and clarify complex concepts. In addition, the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.

Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease, the book sets readers on a new, more promising path to understanding the origins of cancer and developing new, more effective strategies to treat and prevent it.

Résumé
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited.

Contenu

Forword xiii

Preface xv

1. Images of Cancer 1

How Cancer is Viewed 2

References 13

2. Confusion Surrounds the Origin of Cancer 15

The Oncogenic Paradox 18

Hallmarks of Cancer 18

Reassessment 26

References 27

3. Cancer Models 31

Problems with Some Cancer Models 31

Animal Charges as a Major Impediment to Cancer Research 38

Problems with Tumor Histological Classification 39

Personal Perspective on Cancer 44

References 45

4. Energetics of Normal Cells and Cancer Cells 47

Metabolic Homeostasis 47

The Constancy of the G'ATP 54

ATP Production in Normal Cells and Tumor Cells 55

Energy Production Through Glucose Fermentation 57

Glutaminolysis with or without Lactate Production 61

Transamination Reactions 64

TCA Cycle, Substrate-Level Phosphorylation 66

Cholesterol Synthesis and Hypoxia 67

Summary 67

References 68

5. Respiratory Dysfunction in Cancer Cells 73

Normal Mitochondria 74

Morphological Defects in Tumor Cell Mitochondria 77

Proteomic Abnormalities in Tumor Cell Mitochondria 79

Lipidomic Abnormalities in Tumor Cell Mitochondria 81

Cardiolipin: A Mitochondrial-Specific Lipid 83

Cardiolipin and Abnormal Energy Metabolism in Tumor Cells 85

Complicating Influence of the In Vitro Growth Environment on Cardiolipin Composition and Energy Metabolism 92

Mitochondrial Uncoupling and Cancer 97

Cancer Cell Heat Production and Uncoupled Mitochondria 98

Personal Perspective 99

Summary 100

References 101

6. The Warburg Dispute 107

Sidney Weinhouse's Criticisms of the Warburg Theory 108

Alan Aisenberg's Criticisms of the Warburg Theory 110

Sidney Colowick's Assessment of the Aisenberg Monograph 113

Apples and Oranges 114

References 116

7. Is Respiration Normal in Cancer Cells? 119

Pseudo-Respiration 119

How Strong is the Scientific Evidence Showing that Tumor Cells can Produce Energy Through OxPhos? 124

OxPhos Origin of ATP in Cancer Cells Reevaluated 124

What About OxPhos Expression in Other Tumors? 127

The Pedersen Review on Tumor Mitochondri…