Toxicology and Epigenetics

Informationen zum Autor Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, 2007), Toxicogenomics (Wiley, 2008), Nanotoxicity (Wiley, 2009), and Handbook of Systems Toxicology (Wiley, 2011). Klappentext Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics - impact for drug safety sciences methods of global epigenomic profiling* transcriptomics: applications in epigenetic toxicologyToxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government. "Despite some of the issues with the structure, Toxicology and Epigenetics is an important, timely book that provides world-class, expert opinion on a broad range of topics in a fast moving highly relevant branch of toxicology." ( British Toxicology Society , 1 July 2013) Zusammenfassung This book describes cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts considers the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. This book offers essential insights into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators. Inhaltsverzeichnis Preface xxi Acknowledgments xxiii List of Contributors xxv 1 Introduction 1 Saura C. Sahu References 2 2 Environment, Epigenetics, and Diseases 5 Robert Y.S. Cheng and Wan-yee Tang 2.1 Perceptions of epigenetics 5 2.2 Environmental epigenetics and human diseases 8 2.3 Implications of environmental epigenetics and future prospects 16 2.4 Key questions to be answered 17 Acknowledgments 17 References 17 3 DNA Methylation and Toxicogenomics 25 Deepti Deobagkar 3.1 Introduction 25 3.2 Toxicology 26 3.3 Tox...

Auteur

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.
Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, 2007), Toxicogenomics (Wiley, 2008), Nanotoxicity (Wiley, 2009), and Handbook of Systems Toxicology (Wiley, 2011).

Texte du rabat
Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics - impact for drug safety sciences methods of global epigenomic profiling * transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Résumé
This book describes cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts considers the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. This book offers essential insights into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators.

Contenu

Preface xxi

Acknowledgments xxiii

List of Contributors xxv

1 Introduction 1
Saura C. Sahu

References 2

2 Environment, Epigenetics, and Diseases 5
Robert Y.S. Cheng and Wan-yee Tang

2.1 Perceptions of epigenetics 5

2.2 Environmental epigenetics and human diseases 8

2.3 Implications of environmental epigenetics and future prospects 16

2.4 Key questions to be answered 17

Acknowledgments 17

References 17

3 DNA Methylation and Toxicogenomics 25
Deepti Deobagkar

3.1 Introduction 25

3.2 Toxicology 26

3.3 Toxicogenomics 27

3.4 Epigenetics 29

3.5 DNA methylation 30

3.6 DNA methyltransferases 34

3.7 DNA methylation is alteres upon exposure to chemicals and toxins 35

3.8 Toxicogenomics and epigenetics 40

3.9 Hydroxymethyl cytosine and toxicogenomics 42

3.10 MicroRNAs 42

3.11 DNA methylation in cancer 42

3.12 Bioinformatics approach 44

3.13 Summary 45

Acknowledgments 46

References 46

4 Chromatin at the Intersection of Disease and Therapy 51
Delphine Quénet, Marcin Walkiewicz, and Yamini Dalal

4.1 Epigenetic marks on chromatin: a complex pathway with high flexibility 51

4.2 Epigenetic approaches to treatme…