Neuropathology of Aging and Alzheimers Disease

Auteur
Dr. Rudolph J. Castellani is a pathologist in Baltimore, Maryland and is affiliated with multiple hospitals in the area, includingWest Virginia University HospitalsandDavis Medical Center. He received his medical degree from Wayne State University School of Medicine and has been in practice for more than 20 years. He specializes in Pathology, Neuropathology and Anatomic Pathology. He's published hundreds of articles, and has received ~19 honors and awards. Dr. George Perry, Ph.D. Professor of Biology and Chemistry

Semmes Foundation Distinguished University Chair in Neurobiology

He is a neuroscientist known for his work on neuronal oxidation of nucleic acids inAlzheimer's disease. He is distinguished as one of the top Alzheimer's disease researcherswith over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.Dr. Jamshidi received his MD from Weill Cornell Medicine, followed by a year of internship in Obstetrics and Gynecology at New York-Presbyterian Hospital. He then pursued an NIH-funded post-doctoral fellowship at the Mesulam Center for Cognitive Neurology and Alzheimer's Disease at Northwestern University Feinberg School of Medicine. He completed Anatomic Pathology residency at University of Chicago NorthShore and a fellowship in Neuropathology at Northwestern Memorial Hospital. He then joined the Department of Pathology at Northwestern University Feinberg School of Medicine. His academic interests include medical education, advanced molecular diagnostics in neuropathology and neurodegenerative diseases.

Texte du rabat

Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.

Contenu

1. Historical evolution of Alzheimer’s disease and age-related pathology from Alzheimer forward
   
   2. Introduction to the neuroanatomy of AD
   3. Neurohistologic techniques and methodology
   4. Plaque pathology
   5. Neurofibrillary degeneration
   6. Other Alzheimer disease and age-associated pathology - granulovacuolar degeneration, Hirano bodies, cerebral amyloid angiopathy
   7. Consensus efforts for dementia brain interpretation at autopsy
   8. Pathology of autosomal dominant Alzheimer’s disease and Down syndrome
   9. Aging-related tau - primary age-related tauopathy, aging-related tau astrogliopathy, argyrophilic grain disease
   10. TDP-43 in aging and Alzheimer’s disease
   11. Cerebrovascular disease and cognition
   12. Challenges with clinicopathological correlation
   13. COVID and Alzheimer’s disease
   14. Ethical considerations in the neuropathological diagnosis of AD
   15. Neuropathology and the so-called amyloid cascade
   16. The diagnostic process in neurodegenerative diseases, including ethical considerations