Metal Complexes in Aqueous Solutions

Stability constants are fundamental to understanding the behavior of metal ions in aqueous solution. Such understanding is important in a wide variety of areas, such as metal ions in biology, biomedical applications, metal ions in the environment, extraction metallurgy, food chemistry, and metal ions in many industrial processes. In spite of this importance, it appears that many inorganic chemists have lost an appreciation for the importance of stability constants, and the thermodynamic aspects of complex formation, with attention focused over the last thirty years on newer areas, such as organometallic chemistry. This book is an attempt to show the richness of chemistry that can be revealed by stability constants, when measured as part of an overall strategy aimed at understanding the complexing properties of a particular ligand or metal ion. Thus, for example, there are numerous crystal structures of the Li+ ion with crown ethers. What do these indicate to us about the chemistry of Li+ with crown ethers? In fact, most of these crystal structures are in a sense misleading, in that the Li+ ion forms no complexes, or at best very weak complexes, with familiar crown ethers such as l2-crown-4, in any known solvent. Thus, without the stability constants, our understanding of the chemistry of a metal ion with any particular ligand must be regarded as incomplete. In this book we attempt to show how stability constants can reveal factors in ligand design which could not readily be deduced from any other physical technique.

Texte du rabat

This unique reference details current research on the formation and stabilities of metal complexes, chelates, macrocyclic complexes, and cryptates in aqueous solutions. Chapters thoroughly describe the principles of ligand design and their application to a wide variety of metal ions. In addition, the text examines medicinal and biochemical applications of metal complexes. This work will make an invaluable supplementary text for advanced inorganic chemistry courses.

Contenu
1 Introductory Overview.- 2 Factors Governing the Formation of Complexes with Unidentate Ligands in Aqueous Solution. Some General Considerations.- 3 Chelating Ligands.- 4 Complexes of Macrocycles and Other More Highly Preorganized Ligands.- 5 Medical Applications of Metal Complexes.- 6 The Selectivity of Ligands of Biological Interest for Metal Ions in Aqueous Solution. Some Implications for Biology.- 7 Stability Constants and Their Measurement.