Recent Advances in Hemodynamics and Blood Mimetics

Texte du rabat

Recent Advances in Hemodynamics and Blood Mimetics is a comprehensive compilation of recent developments in biofluid mechanics and biomimetics, covering topics such as numerical modelling, biomedical applications of microfluidics, biomimetic flows, biomedicine applications, and organ-on-chip technology. This book explores blood hemodynamics at different scales, including application to diseases, the relationship between blood biomechanics and rheology, the mimetisation of blood properties at arterial and capillary level, including the study of blood mechanical and flow properties, flow and surface properties of blood cells, mimetisation of these same properties in fluid/particle systems. These concepts are applied to the development of organ-on-chip to improve the replication of biological processes in the human body. The book organizes recent knowledge on hemodynamics and blood mimetics and is representative of the different lines of research in the field, showing an integrated view of blood biomechanics encompassing all scales to create a valuable resource where different research lines can be found and their principles understood.

Contenu

Section 1. Numerical methods 1. Patient specific hemodynamics 2. Two-phase flows (VOF method, Euler-euler methods, Euler-Lagrange methods) 3. Macroscopic rheological properties estimated from microstructure of particle suspension 4. Dissipative Coupling of Fluid and Immersed Objects for Modelling of Cells in Flow 5. Flow of blood cells in microfluidic channels: a dissipative particle dynamics simulation study Section 2. Biomedical applications of microfluidics 6. Biomechanics of blood cells 7. Techniques to fabricate microparticles for hemodynamic applications 8. Hemodynamics in the Microcirculation and in Microfluidics 9. Applications of inertial microfluidics in biomedical research 10. Properties and applications of PDMS microfluidic devices 11. In vitro hemodynamics Section 3. Biomimetics and bioinspired flows 12. Review on blood analogue fluids 13. Murray’s Law in blood vessel networks 14. Mechanical behavior of bio-inspired systems 15. Flow in microfluidic systems using networks of bio-inspired soft valves 16. Biomimetics of the pulmonary environment in vitro Section 4. Applications to biomedicine 17. Gas embolisms in small vessels - formation, vessel clogging, flow 18. Pathological Hemodynamics 19. Flow Visualizations in PDMS Cerebral Aneurysm Biomodel 20. Blood flow in a cerebral aneurysm 21. Mechanical characterization of pathological blood Section 5. Micro and nano flow applications in organ on chips 22. PDMS surface modification for microfluidic devices and organ on chip platforms 23. Flow assessment and analysis of oxygen transport in an organ on chip platform 24. Micro/Nanomachines for biomedical applications 25. Effects of microneedle design parameters on hydraulic resistance 26. PDMS Microneedles for organ-on-chip platforms