Progenitor Cell Therapy for Neurological Injury

This compilation of seminal essays provides an up-to-date and focused review on non-embryonic progenitor cell therapeutics for neurological injuries. The book aims to provide a vital key toward unlocking future treatments for severe neurological injury.

There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.

The text provides an up-to-date focused review on non-embryonic progenitor cell therapeutics for neurological injuries Translational barriers to adoption of progenitor based cell therapeutics is a central theme of the text This is a single source for a broad overview of the status of pre-clinical proof of concept data and early translational trials using progenitor cells for neurological injury Includes supplementary material: sn.pub/extras

Contenu
Preface.- Chapter 1. Basics of Stem and Progenitor Cells.- Chapter 2. Progenitor Cell Tissue Engineering: Scaffold Design and Fabrication.- Chapter 3. Stem Cell Delivery Methods and Routes.- Chapter 4. Neural Stem Cells-Endogenous Repair of Neurological Injury.- Chapter 5. Traumatic Brain Injury: Pathophysiology and Models.- Chapter 6. Traumatic Brain Injury: Relationship of Clinical Injury to Progenitor Cell Therapeutics.- Chapter 7. Cell-Based Therapy for Stroke.- Chapter 8. Spinal Cord Injury: Pathophysiology and Progenitor Cell Therapy.- Chapter 9. Current Status of Clinical Trials using Progenitor Cells for Neurological Injury