Pioneers in Neuroendocrinology II

This second volume of Pioneers in Neuroendocrinology differs from the first in several respects. First, with one exception, the present writers represent the second generation of pioneers, who began their work in the early or mid-1950s, at the onset of what became the most intensive and fruitful period of neuroendocrine research. Second, with few exceptions, the present authors are still active in work on many aspects of neuroendocri nology and show a keen appreciation of current as well as past problems in the field. Third, this volume covers the period when definite proof for the "chemotransmitter hypothesis" was first provided. This includes work by Saffran, Schally, Guillemin, McCann, Meites, Schreiber, and others demonstrating that "releasing factors" actually are present in the hypothalamus, early attempts to characterize them, development of assay methods, and studies on their physiology. All of this culminated in the dramatic announcements during the second half of 1969 of the isolation and synthesis of the first hypothalamic hypophysiotropic hormone, pyroglutamylhistidylprolinamide (TRH). Guillemin and Schally provide colorful accounts of their early work on this and other hypothalamic releas ing factors. Both received Nobel prizes for their achievements.

Contenu

1. Adventures with the Androgen-Sterilized Rat and Reproductive Neuroendocrinology.- 2. Confessions of an Imposter.- 3. A Second-Generation Neurosecretionist Looks at His Field.- 4. Gullible's Travails: or How I Eventually Discovered the Implantation Paradox.- 5. Tracking the Elusive CRF.- 6. Brain, Breast, and Gonads: A Passage in Neuroendocrinology.- 7. From Tadpole to TRF.- 8. Portal Vessels and Puberty.- 9. Development of Neuroendocrine Research in the Institute of Physiology at the Medical School of the University of Pécs, Hungary.- 10. Searching for the Clocks of Metamorphosis.- 11. Neurohormonal Feedback Control of Gonadotropin Secretion.- 12. The Brain and the Endocrine System: A Memoir.- 13. Why I Am Still Waiting for a Free Trip to Stockholm.- 14. Pioneering in Neuroendocrinology 1952-1969.- 15. The Hypophysiotropic Area.- 16. A Retrospect with Nostalgia.- 17. In Search of Hypothalamic Hormones.- 18. Studies on Neuroendocrine Control of Prolactin and Other Anterior Pituitary Hormones.- 19. Formative Years as an Investigator of Hypothalamic-Pituitary Physiology.- 20. Corticotropin-Releasing Factor: The Elusive Hormone.- 21. In the Pursuit of Hypothalamic Hormones.- 22. Being an Outsider.- 23. Pituitary Peptides and Adaptive Behavior.- 24. A Skeptical Neuroendocrinologist.