Pathobiology of Parasitic Protozoa: Dynamics and Dimensions

This book illustrates the importance and significance of the systems approach in deciphering diverse aspects of host-parasite interactions in infection dynamics. It describes the complex issues and state-of-the-art progress in the infection biology of parasitic protozoa. The book explores the current concepts and paradigms of gene expression, metabolome, and immune remodeling in these diseases. The chapters encompass updates on the parasitic tropism, co-evolution, systemic responses in hosts, and translational approaches. It provides an overview of the parasite's efficient ways of exploiting host molecules and describes pathways for their survival, differentiation, and replication within the host cells. The book also delineates the role of inflammasomes and their activation in response to the protozoan parasite. The book discusses technological progress and machine learning-based modeling approaches to revisit parasitic infection from a non-conventional perspective. Collectively this book offers a comprehensive purview of concepts and paradigms in parasitic infection in the form of an updated yet discernible elucidation.

Presents systems analysis of host-parasite interactions Discuses metabolome and immune remodeling during protozoan infection Reviews the role of endosymbionts in host-parasite co-evolution

Auteur

Dr. Budhaditya Mukherjee is an Assistant Professor at the School of Medical Science and Technology, IIT Kharagpur, India. His research interests primarily articulate around immunological and cellular aspects of host-pathogen interactions for intracellular protozoan pathogens that enable them to survive within the hostile host environment. He has been serving as a reviewer in a number of reputed international journals like PLOS Neglected Tropical Diseases, Molecular Microbiology, Frontiers in Immunology to name a few and is an editorial board member of several journals, including Frontiers in Cellular and Infection Microbiology. He has been conferred with various prestigious international and national awards notably the EMBO Post-Doctoral Fellowship, Pfizer Research Award in the area of infectious diseases, rheumatology, and immunology, INSA Medal for Young Scientist. He is a member of many American Society of Microbiology He has more than 11 years of research and teaching experience in Infection biology, Immunology, Cell and molecular biology.

Dr. Arijit Bhattacharya is an Associate Professor and Head of the Department of Dept. of Microbiology, Adamas University, India. He has earlier served as Assistant Professor in Presidency College (Kolkata, India) and Tripura Central University, India. His research interests are in molecular parasitology, anti-microbial resistomics, and drug designing exploiting evolutionary approaches. He has served as a referee for several international journals, including PLOS Neglected Tropical Diseases, iScience, Frontiers in Pharmacology, Infection, genetics, evolution, Parasites and Vectors, PLOSone, and Access Microbiology (Microbiology Society, UK). He is a member of many international scientific societies and organizations, notably the American Society of Microbiology, Genetics Society of America, and Society for Biological Chemists (India).

Dr. Rupkatha Mukhopadhyay is an Associate Researcher at the Department of Hematologic Malignancies, Johns Hopkins School of Medicine, Maryland, USA. Her research interests primarily encompass identifying predictive markers on the immunologic cells that are mainly responsible for disease prognosis. She has been serving as a reviewer for several reputed international journals like Journal of Clinical Investigation, PLOS Neglected Tropical Diseases, PLOS One, BMC Cancer, BMC Research Notes, Frontiers in Cellular and Infection Microbiology, and Cancer Cell International. Dr. Rupkatha has been conferred with the prestigious ASH BMT New Investigator award in the area of hematologic malignancy.

Dr. Bruno Guedes Alcoforado Aguiar is an Assistant Professor at the Department of Community Medicine, Federal University of Piauí, Brazil. His research interests are in molecular parasitology, regulation of gene expression, microbial pathogenesis and genomics. He has served as a referee for international journals and have published research articles at peer-reviewed international journals including Cell Microbiology, Scientific Reports, and Cell Death and Disease. He is a scientific board member at the Research Center for Emerging and Neglected Tropical Diseases, Piauí, Brazil.

Contenu

1.Nanotechnology-based promising therapeutic approaches against protozoan.- 2. Intertwining of retinoic acid and cholesterol pathway and its consequences in Leishmania donovani infected macrophages.- 3. Role and pathophysiology of protozoan parasites causing liver diseases.- 4. Cognitive Impairment in Parasitic Protozoan Infection.- 5. Cycling Within a Cell: Cell Cycle of Intracellular Kinetoplastid Parasites.- 6. Elaborating role of aspartyl protease in host modulation and invasion in Apicomplexan parasites Plasmodium and Toxoplasma.- 7. Leishmaniasis: Tissue tropism in relation to the species diversity.- 8. Transcriptional control in Entamoeba: Something old, Something new.- 9. A perspective on mathematical modeling and machine learning models to predict Visceral Leishmaniasis.- 10. Elucidating the Role of miRNA in Inflammasome Mediated Immune Response in Leishmaniasis.- 11. An Insight into Immunopathology of Leishmaniasis.