Nutrition, Exercise and Epigenetics: Ageing Interventions

This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena.

Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

Offers timely reviews on research into aging intervention Explores epigenetic modulation of aging by nutrition and exercise Reports on a case study measuring the effects of calorie restriction in non-human primates Includes supplementary material: sn.pub/extras

Résumé

"This volume in the Healthy Ageing and Longevity series is a compilation of the current research highlighting the benefits of nutrition and physical activity on components of health, primarily aging. ... It is appropriate for those who have a very good understanding of current research and methodology. ... This book certainly has a place for researchers who wish to expand upon the growing animal model evidence of the potential benefits of nutrition and physical activity on aging." (Amy Hess-Fischl, Doody's Book Reviews, April, 2015)

Contenu
Preface.- Epigenetics and Nutrition.- Calorie restriction as a potent epigenetic modifier.- Anti-inflammatory action of calorie restriction for aging intervention.- Hormonal influence and modulation on aging.- Epigenetic modification by exercise.- Physiological bases and underlying mechanisms of exercise.- Sarcopenia and its intervention.- Nutritional impacts on osteopenia and osteoporosis.- Nutritional interventions for cardiac aging and age-related cardiovascular diseases.- Nutritional influence on aging brain.- Mechanistic bases of calorie restriction mimetics.- Lessons learned from calorie restricted non-human primate research.