Age Later: Healthspan, Lifespan, and the New Science of Longevity

Informationen zum Autor Nir Barzilai, M.D. Klappentext How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don't? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai's life's work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including "the big four": diabetes, cancer, heart disease, and Alzheimer's. One of Dr. Barzilai's most fascinating studies features volunteers that include 750 SuperAgers-individuals who maintain active lives well into their nineties and even beyond-and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later , Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon-like many other diseases and misfortunes-that can be targeted, improved, and even cured. Inhaltsverzeichnis Introduction 1. One Hundred Years Young The Mysteries of Aging What Makes SuperAgers Stay Healthy? Studying Centenarians Designing a Study Without a Control Group Meeting Our First AJ Centenarians and Their Offspring A Perfect Genome? Centenarians' Interactions with Their Environments Do as I Say, Not as I Do 2. Why We Age Recent Theories The Search for Protection from Aging Eating Less May Lead to More Healthy Years Unlocking the Secrets in Fat Caloric Restriction: A Mixed Bag of Effects Aging Begins Before We're Born SuperAgers' Top Secrets 3. Cholesterol: Is More Better? Unlocking Cholesterol's Longevity Secrets Are there Really Good Gene Mutations? Solving the Mystery of Helpful Gene Mutations The Benefits of CETP Personified A Mutation That Adds Years to Life Span? 4. Growth Hormone: Less Is More Less Growth May Lead to an Exceptionally Long Life Growth Hormone Clues from Our Centenarians Epigenetic Mechanisms Can Increase Longevity Making the Most of Our Findings Growth Hormones Don't "Grow" Life Span 5. Unraveling the Longevity Mystery Deep Inside Our Cells A Match Made on Earth Mitochondria's Hidden Purpose Resilient to the End A CohBar Is Born Searching for Promising Peptides 6. The Quest to Prove Aging Can Be Targeted Choosing an Existing Drug to Prove Our Point Getting the FDA on Board How the TAME Study Works Who's Going to Pay for All This? Metformin Is the Tool, Not the Goal 7. Making Eighty the New Sixty The Price of Progress Collaboration Is the Key to Speed Long, Healthy Life Span Versus Immortality The Gap Between Making Drugs and Making Drugs Available 8. Stop the Clock How Old Is Old? Use It or Lose It Antioxidants and Hormesis Thriving in the Shadow of Stress Preventing the Loss of Muscle Mass as We Age Exercise Plus Metformin Feeding Our Longevity Hydrating Wisely Prevent Obesity Nutraceuticals Are in the Works The Magic Pills We've Been Wishing For When We Eat Matters Our DNA Has Something to Say Stay Mentally Sharp Other Promising Practices How to Decide What's Good for You 9. Bright Horizons The Unparalleled Power of Omics Personalized Medicine Advances in Early Detection Pione...

Auteur

Nir Barzilai, M.D.

Texte du rabat

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don't? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties?

Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai's life's work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including "the big four": diabetes, cancer, heart disease, and Alzheimer's.

One of Dr. Barzilai's most fascinating studies features volunteers that include 750 SuperAgers-individuals who maintain active lives well into their nineties and even beyond-and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline.

In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon-like many other diseases and misfortunes-that can be targeted, improved, and even cured.

Contenu

Introduction

1. One Hundred Years Young
The Mysteries of Aging
What Makes SuperAgers Stay Healthy?
Studying Centenarians
Designing a Study Without a Control Group
Meeting Our First AJ Centenarians and Their Offspring
A Perfect Genome?
Centenarians' Interactions with Their Environments
Do as I Say, Not as I Do

2. Why We Age
Recent Theories
The Search for Protection from Aging
Eating Less May Lead to More Healthy Years
Unlocking the Secrets in Fat
Caloric Restriction: A Mixed Bag of Effects
Aging Begins Before We're Born
SuperAgers' Top Secrets

3. Cholesterol: Is More Better?
Unlocking Cholesterol's Longevity Secrets
Are there Really Good Gene Mutations?
Solving the Mystery of Helpful Gene Mutations
The Benefits of CETP Personified
A Mutation That Adds Years to Life Span?

4. Growth Hormone: Less Is More
   Less Growth May Lead to an Exceptionally Long Life
   Growth Hormone Clues from Our Centenarians
   Epigenetic Mechanisms Can Increase Longevity
   Making the Most of Our Findings
   Growth Hormones Don't "Grow" Life Span

5. Unraveling the Longevity Mystery Deep Inside Our Cells
A Match Made on Earth
Mitochondria's Hidden Purpose
Resilient to the End
A CohBar Is Born
Searching for Promising Peptides

6. The Quest to Prove Aging Can Be Targeted
Choosing an Existing Drug to Prove Our Point
Getting the FDA on Board
How the TAME Study Works
Who's Going to Pay for All This?
Metformin Is the Tool, Not the Goal

7. Making Eighty the New Sixty
The Price of Progress
Collaboration Is the Key to Speed
Long, Healthy Life Span Versus Immortality
The Gap Between Making Drugs and Making Drugs Available

8. Stop the Clock
How Old Is Old?
Use It or Lose It
Antioxidants and Hormesis
Thriving in the Shadow of Stress
Preventing the Loss of Muscle Mass as We Age
Exercise Plus Metformin
Feeding Our Longevity
Hydrating Wisely
Prevent Obesity
Nutraceuticals Are in the Works
The Magic Pills We've Been Wishing For
When We Eat Matters
Our DNA Has Something to Say
Stay Mentally Sharp
Other Promising Practices
How to Decide What's Good for You

9. Bright Horizons
The Unparalleled Power of Omics
Personalized Medicine
Advances in Early Detection
Pioneering Explorations
Reversing Cellular Age
Genetic Engineering

Acknowledgments
Index