Cyanoximes

Auteur
Nikolay Gerasimchuk obtained his first Ph.D. in Inorganic Chemistry from Kiev State University, Ukraine, and his second Ph.D. in Bioinorganic Chemistry from the University of Kansas, USA. He is currently a Distinguished Professor at Missouri State University, USA, where over 22 years he teaches several classes of inorganic chemistry curriculum. His research interests are synthesis, spectroscopic characterization and medical-biological applications of oxime-based ligands and their metal complexes for which he acquired 9 patents. His publications include 138 papers, two book chapters, a laboratory manual book and three editorials in special edition issues of Current Inorganic Chemistry and Molecules.

Texte du rabat

During the last three decades research interests were dedicated to the new subclass of organic ligands - cyanoximes. With 38 different R groups the most abundant is the family of mono-cyanoximes, followed by 7 bis-cyanoximes that include aromatic and aliphatic spacers, and lately 2 tris-cyanoximes - a tripod type of ligands - was obtained and characterized. These simple low molecular weight organic molecules represent series of new excellent ampolydentate ligands for coordination chemistry. Currently 48 cyanoximes are known, and there were more than two hundreds cyanoxime complexes synthesized and studied using a variety of different spectroscopic methods and X-ray analysis. Methods of syntheses, stereochemistry of cyanoximes ligands, their structures and properties, as well as the most interesting coordination compounds are described in this book, as well as a broad spectrum of practical applications of both cyanoximes, and their metal complexes. Cyanoximes: Chemistry, Coordination and Organometallic Compounds and their Applications contains information about practical aspects of presented compounds including established structure-biological activity trends which may be very useful for discovery of new drug candidates that further may be developed into drugs. This book contains vast information about the use of cyanoximes as small molecules ligands in coordination, bioinorganic and organometallic chemistry. It also presents structural chemistry of these compounds and shows their most interesting spectroscopic properties, coupled with practical aspects of their chemistry.

Contenu

Introduction

1. PART 1.
1.1. Oximes: intermediate compounds between amines and nitro-compounds
1.2. Types of oximes
1.3. Currently known and studied cyanoximes
1.3.1. Methods of syntheses of cyanoximes
1.3.2. Selected examples of syntheses of several cyanoximes, their identification and characterization
1.3.3. Crystallographically identified products of side reactions during syntheses of cyanoximes
1.3.4. Chemical modifications of cyanoximes leading to other useful compounds
1.4. Stereochemistry of cyanoximes
1.4.1. Re-isomerization of cyanoximes: thermodynamic aspects.
1.4.2. Co-crystallization of syn-/anti-diastereomers of cyanoximes: structural and spectroscopic evidence
1.5. Deprotonation of cyanoximes and formation of colored anions
1.6. UV-visible spectra of anionic cyanoximes: solvatochromism.
1.7. Solid state structures of ionic salts of cyanoximes
1.8. Formation of unique acid-salts of monoprotic cyanoximes: structural aspects.
1.9. Cyanoxime anions are unique ampolidentate ligands for coordination and organometallic chemistry!

2. PART 2: Werner-type complexes.
2.1. Rationale and motivation for the synthesis of metal-containing cyanoximates.
2.2. Preparation of Werner-type coordination compounds involving oximes.
2.2.1. Selected examples of syntheses of several complexes, their isolation and characterization.
2.3. Structural chemistry of thallium(I) cyanoximates
2.4. Chemistry of lead(II) cyanoximates
2.5. Transition metals cyanoximates
2.5.1. Silver(I) cyanoximates: structures and properties
2.5.2. Complexes of Zn2+, Ni2+, Cu2+, Co3+ and their properties
2.5.3. Intensely colored complexes of Fe2+ and in solid state and solutions

3. PART 3: organometallic cyanoximates.
3.1. Purpose for synthesis and characterization of series of organometallic compounds
3.2. Organotin(IV) cyanoximates
3.3. Organoantimony(V) cyanoximates
3.4. Organotellurium(IV) compounds.

4. PART 4: developed applications and potential usefulness of cyanoximes and their metal complexes.
4.1. Biomedical field.
4.1.1 Halo-aryl-cyanoximes as enzymes inhibitors
4.1.2. Antimicrobial properties of Ni2+ and Cu2+ cyanoximates
4.1.3. Visible light insensitive silver(I) cyanoximates
4.1.4. New non-antibiotic antimicrobial organoantimony(V) compounds
4.1.5. Novel cytotoxic organotin(IV) compounds
4.1.6. In vitro cytotoxic Pd and Pt cyanoximates with minimal side effects in vivo
4.2. Technological areas.
4.2.1 New conducting Pt-based molecular NIR emitters
4.2.2 Catalytic function of some Zn2+cyanoximates
4.2.3 Potentially high-energy compounds of cyanoximates of Ni, Cu and Pb
4.2.4 Visible light insensitive silver(I) cyanoximates

5. Afterward

6. Acknowledgment