Nanoscale Insights into Ion-Beam Cancer Therapy

This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.

The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development incancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.

The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.

Presents a comprehensive overview of our understanding of ion-beam cancer therapy at the molecular level Offers a consistent multiscale approach to the problem of radiation biodamage and its application to ion-beam cancer therapy Contributes state-of-the-art knowledge gained by the international community during the COST Action Nano-IBCT (Nanoscale Insights into Ion-Beam Cancer Therapy) Includes supplementary material: sn.pub/extras

Auteur
Professor Andrey Solov'yov is Editor-in-Chief of EPJD Atomic, Molecular, Optical and Plasma Physics from January 2015. He is Scientific and Executive Director of the MBN Research Center, Frankfurt am Main, Professor at the Peter the Great Saint-Petersburg Polytechnic University and the Leading Research Fellow at the A.F. Ioffe Physical-Technical Institute, Russian Academy of Sciences, Correspondent Member of European Academy of Sciences, Arts and Literature, Coordinator of several large European Projects in the interdisciplinary fields of Physics, Chemistry, Biology and Material Science, author / co-author of large number of research articles in high impact journals and books.

Contenu
Multiscale Physics of Ion-Beam Cancer Therapy.- Theory of atomic and molecular collisions, quantum and classical molecular dynamics (theory).- Fundamental collisions (experiment, both electrons and ions, stress on biomolecules).- Dissociative electron attachment process.- Ions propagation through biological medium.- Irradiation of biological targets with ions.- Monte Carlo track structure simulations.- Radiation nanochemistry.- Radiobiological effects.- Advanced therapies based on nanoprocesses and technologies: radiobiological effects with nanoparticles.- Treatment planning systems.- Medical applications (overview of the heavy ion therapy medical centers and practices).