Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration

This book integrates the current basic and clinical knowledge in the area of biophysical stimulation of osteoblast for in vitro and in vivo live bone generation. This innovative methodology and its applications are presented and discussed in several clinical conditions: treatment of fracture nonunion, spine stabilization, bone replacement after tumor resections, stabilization of failed joint endoprostheses in revision surgery and in treatment of bone loss (osteoporosis and osteopenia). The author analyses different types of biophysical stimulation of osteoblasts for bone regeneration, e.g. mechanical (static and alternating, including distraction osteogenesis), electromagnetic (pulsed, alternating, static), light (at different spectrum range, including laser), acoustic (including ultrasound), RF etc. Moreover, he summarizes and discusses the most significant findings for in vitro bone generation and its resulting clinical use as autologous bone graft without surgical morbidity. Reflecting the author's extensive experience this book is an excellent source of knowledge and a valuable aid to clinical practice for all orthopedic surgeons, fellows, and researchers wanting to gain insights into this promising field.

Presents innovative data of in vitro live bone generation Offers an overview of biophysical osteoblast stimulation techniques Integrates basic science and clinical knowledge

Auteur

Rosenberg Nahum MD, PhD, MOrthop (Hons.), MBA , FRCS (England), is a Consultant Orthopedic surgeon with more than 30 years of professional experience. Dr. Rosenberg earned the MD degree from the Faculty of Medicine in Technion - IIT in 1990. The final thesis was written on the outcome of spinal fractures and was awarded with high distinction. He accomplished his clinical residency in Orthopedic Surgery in Rambam Medical Center, Haifa in 1997. He was extensively involved in basic research, which led to the MOrthop (Distinct) degree From Tel Aviv University in 1996. In 1998-9 he was appointed as a Nuffield fellow in Orthopedic Surgery in Oxford University UK and 1999 as a clinical fellow in orthopedics in Mercy Private Hospital, Melbourne, Australia. Then in 2002, he was appointed as a Clinical Fellow in Orthopedic Surgery (Upper limb surgery) at the University of Nottingham UK. In 2018 he accomplished the MBA degree with a specialization in Biomedicine at the College of Management Academic Studies, Israel.

Since 2003 he served as a Senior orthopedic surgeon in Rambam Health Care Campus, Haifa. Appointed as Assistant Clinical Professor in the Faculty of Medicine, Technion -IIT in 2007, and in 2018, as a Professor in the Department of Traumatology, Orthopedic Surgery, and Disaster Medicine in IM Sechenov First Moscow State Medical University. His scientific activity concentrated on bone tissue regeneration's basic and clinical research that led to the Ph.D. degree at the University of Portsmouth, UK.

Dr. Rosenberg is an active Member of Editorial boards in 8 scientific journals. Member of Shoulder Committee of ISAKOS (International Society of Arthroscopy, Knee Surgery and Orthopedic Sports Medicine), author of 80 peer-reviewed scientific publications, editor of 4 books, and 150 presentations at international scientific meetings. His main research interests are osteoblast physiology, bone biology, bone regeneration, shoulder surgery, orthopedic procedures, and human biomechanics. The primary clinical expertise is in shoulder surgery.

Contenu
1 Theoretical framework supporting the research of biophysical stimulation of osteoblasts.- 2. Methodologies used and their rationale.- 3. Osteoblast explant cultures.- 4. End parameters.- 5. Determination of in vitro generated tissue.- 6. In vitro safety studies.- 7. In vivo safety evaluation.- 8. Efficacy in vivo studies.- 9. Setups for external application of biophysical energy.- 10. Mechanical stimulation.- 11. The original contribution to knowledge.- 12. Contribution to developing the theory in the field.- 13. The impact of the work on professional practice.- 14. The nature of the work's academic impact.- 15. The strengths and weaknesses of the methodologies used (critical analysis).- 16. Conclusion.