Models, Molecules and Mechanisms in Biogerontology

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Elaborates on the different cellular, biochemical and molecular changes that occur during aging Highlights the causes that offset various health conditions associated with aging Recommends important remedies like dietary restrictions and natural products as anti-aging methods to adopt

Auteur
Pramod C. Rath is a Professor of Molecular Biology at the School of Life Sciences, Jawaharlal Nehru University, New Delhi. He received his Ph. D. in 1988 from the Banaras Hindu University. He did his post-doctoral research at the Institute for Molecular Biology I, University of Zurich, ETH-Hoenggerberg from 1989 to 1990 on "Regulation of Interferon Gene Expression in Mammalian Cells" with Prof. Charles Weissmann, Director.
He has 25 years of teaching and research experience, having mentored 17 Ph. D. and 3 M. Phil. students. He has published his research in reputed international journals, such as, Ageing Research Reviews, Molecular Neurobiology, Journal of Molecular Neuroscience, International Journal of Developmental Neuroscience, International Journal of Biological Macromolecules, RNA Biology, PLos One etc. He has published a Springer book, titled 'Topics in Biomedical Gerontology' in 2017.
He has been a recipient ofseveral awards including the A. B. Mishra award for being the gold-medalist during his M. Sc; the Council of Scientific and Industrial Research fellowship for completing his Ph. D.; Swiss National Fund post-doctoral fellowship; Young Scientist research project of the Department of Science and Technology, Government of India, 1993-95; etc. He is a life member of many scientific bodies, including Vice-President of the Association of Gerontology, India (AGI), Indian Immunology Society (IIS), Indian Society of Cell Biology (ISCB) etc. He is a reviewer for many reputed journals, such as Cancer Investigations, DNA and Cell Biology, Indian Journal of Biochemistry and Biophysics, J Genetics, Scientific Reports (NPG), FEBS Letts, BMC Cancer (Biomed Central), Molecular Neurobiology, Neuroscience Letts, Molecular Biology Reports, e-CAM, Biomed. Res. Int., J. Cell. Biochem., Biogerontology etc. He is an Editorial Board member for Frontiers in Cell and Developmental Biology, Switzerland.

Résumé

Contenu
PART I ~ ALTERATIONS IN CELLULAR MECHANISMS DURING AGING.- Chapter 1 Protein Structure and Function in Aging and Age-related Diseases.- Chapter 2 DNA, DNA Replication and Aging.- Chapter 3 Transcription and Aging.- Chapter 4 Ribosomes, Translation and Aging.- Chapter 5 p53 and Aging.- Chapter 6 Paired Box (Pax) Transcription Factors and Aging.- Chapter 7 Telomeres, Telomerase and Aging.- Chapter 8 The Epigenome of Ageing.- Chapter 9 Attaining Epigenetic Rejuvenation: Challenges Ahead.- Chapter 10 Mitochondria as a Key Player in Aging.- Chapter 11 Aging, Free Radicals and Reactive Oxygen Species: An Evolving Concept.- Chapter 12 Stem Cells and Aging.- Chapter 13 Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum .- Chapter 14 Aging: Reading, Reasoning and Resolving Using Drosophila as a Model System.- Chapter 15 Nothobranchius furzeri as a New Model System for Aging Studies.- PART II ALTERATIONS IN METABOLISM DURING AGING AND DISEASES.- Chapter 16 Aging in Muscle.- Chapter 17 Metabolic Diseases and Aging.- Chapter 18 Interplay Between Nutrient Sensing Molecules During Aging and Longevity.- Chapter 19 Protein Aggregation, Related Pathologies and Aging.- Chapter 20 Biological Rhythms and Aging.- Chapter 21 The Biology of Ageing and Cancer A Complex Association.