Models, Molecules and Mechanisms in Biogerontology

Elaborates on the different cellular, biochemical and molecular changes that occur during aging Highlights the implications of aging on the nervous system

Recommends important remedies like dietary restrictions and natural products as anti-aging methods to adopt

Auteur

Pramod C. Rath is a Professor of Molecular Biology at the School of Life Sciences, Jawaharlal Nehru University, New Delhi. He received his Ph. D. in Zoology (Biochemistry) in 1988 from the Banaras Hindu University, Varanasi on the topic 'gene expression during aging' under the supervision of Prof. M. S. Kanungo, who started research on 'biology of aging' in India. He completed his post-doctoral research at the Institute for Molecular Biology I, University of Zurich, Switzerland with Prof. Charles Weissmann, a well-known molecular biologist. He has 27 years of teaching and research experience, having mentored 18 Ph. D. and 4 M. Phil. students. He has published his research in respected international journals, such as Ageing Research Reviews, Molecular Neurobiology, Journal of Molecular Neuroscience, International Journal of Developmental Neuroscience, RNA Biology, PLoS ONE, International Journal of Biological Macromolecules, Molecular Biology Reports, Journal of Biosciences, Biochemical Biophysical Research Communications, Biochimica Biophysica Acta, FEBS Letters, Journal of Clinical Immunology etc. He has published a Springer book, titled 'Topics in Biomedical Gerontology'.

He teaches molecular biology, molecular genetics & genetic engineering and cell signaling to master's and Ph.D. students. Research in his laboratory is focused on cytokines; transcription factors; cell signaling and diseases; genomic biology of repetitive DNA and noncoding RNA; bone marrow stem cells and molecular aging in mammals. He has received numerous awards and fellowships and has been the Vice-President of the Association of Gerontology (India), Acting Dean at the School of Life Sciences. He is a member of several national academic and scientific committees.

Contenu
Part I Alterations in Nervous System, Genes, Hormones and Immunity during Aging. - Neurological problems of the Elderly.- Molecular marker and therapeutic regimen for neurodegenerative diseases.- Neurodegeneration during Aging: Role of Oxidative Stress through Epigenetic Modifications.- Polyglucosan Bodies in Aged Brain and Neurodegeneration: Cause or Consequence?.- Signaling of Nociceptors and Pain Perception: Impact of age.- Association between Ageing and REM sleep loss: Noradrenaline acting as a mediator.- Age related changes in the human retina: a role for oxidative stress. - Ageing: Influence on Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD).- Mitophagy, Diseases and Aging.- Genetics, Ageing and Human Health.- Genetic Syndromes and Aging.- Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging.- Sex Steroids, Cognate Receptors and Aging.- Immunosenesence, Inflammaging and their implications for Cancer and Anemia.- Bone Marrow Stem Cells, Aging and Age-related Diseases.- Part II Interventions for Healthy Aging. - Infantile radiation and Aging Stresses: Effects of Calorie and Dietary Restrictions.- Mechanisms and Late Life Intervention of Aging.- Healthy Ageing and Cancer in Humans.- Nutrition for elderly.- Care of older persons in India: scope of policy and technology tools.