Mitochondrial Inhibitors and Neurodegenerative Disorders

Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mitochondrial electron transport system. Consistent with their ancestry, the mitochondria have their own DNA that encodes many but not all of their proteins. The mitochon dria and their genes come from the mother via the ovum since sperm do not possess mitochondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mitochondrial gene mutations might be a source of human dis ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes.

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Respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The emphasis on 3-NP and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease demonstrate that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. The book also discusses recent therapeutic modalities aimed at rescuing the central nervous system from abnormal mitochodrial functioning. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression.

Résumé
"...is a concise summary of the present state of research in the area of mitochondrial toxins and their role in animal models of neurodegenerative disease."-J Neuropsychiatry Clin Neurosci

Contenu
I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry.- 1 • Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins.- 2 • History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease.- 3 • The Neurochemistry of 3-Nitropropionic Acid.- II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action.- 4 • In Vitro Studies of 3-Nitropropionic Acid.- 5 • Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats.- 6 • Comparative Study on 3-Nitropropionic Acid Neurotoxicity.- 7 • Mechanisms of 3-Nitropropionic Acid Neurotoxicity.- 8 • Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery.- 9 • Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid.- 10 • The 3-Nitropropionic Acid Model of Huntington's Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology?.- 11 • Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery.- 12 • Mitochondrial Inhibition and Neuronal Death in Huntington's Disease.- 13 • Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrance Lipids and Proteins: An Electron Paramagnetic Resonance Investigation.- 14 • Malonate: Profile and Mechanisms of Striatal Toxicity.- 15 • Malonic Acid and the Chronic Administration Model of Excitotoxicity.- 16 • Sodium Azide-Induced Neurotoxicity.- III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity.- 17 • Neuroprotective Strategies Against Cellular Hypoxia.- 18 • Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity.-19 • Neural Transplantation and Huntington's Disease: What Can We Learn from the 3-Nitropropionic Acid Model?.- 20 • Neuroprotective Strategies in Parkinson's Disease and Huntington's Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models.