Metabolism and Epigenetic Regulation: Implications in Cancer

Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases.

The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed.

The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer.
Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer.

Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.

Highlights key metabolic pathways that are deregulated in cancer Covers epigenetic regulations implicated in steering the metabolic programs in cancer cells Provides on overview of epigenetic tools to combat cancer

Auteur
At present Dr. Tapas K Kundu, is the Director of CSIR-Central Drug Research Institute, Lucknow, India. He obtained his PhD from the Indian Institute of Science, Bangalore, in the year 1995. Following his PhD, he had a short stint as a visiting foreign research associate in the National Institute of Genetics, Mishima, Japan, followed by a post-doctoral fellowship at the Rockefeller University, USA. He joined JNCASR, Bangalore in 1999 and became full Professor in 2009. He was a visiting Professor of ENS De Lyon, France and National University of Singapore. Dr. Kundu has made significant contributions in the area of regulation of gene expression and its link to disease and therapeutics. He is not only elucidating the mechanisms of transcription regulation through the epigenetic modifications, but also targeting them to design new generation diagnostics, as well as therapeutics. Over the years, he has published several research papers in many international journals and also edited two books on Epigenetics. Several patent applications from the laboratory have been granted and some are under process, which includes a few academically important research reagents with potential commercial values, some of which have already been commercialized by renowned companies. He is the recipient of several awards, noteworthy among which are: The Shanti Swarup Bhatnagar prize from CSIR, Government of India, the National Academy of Science, India- Reliance Industries Platinum Jubilee Award, the Sir JC Bose National Fellowship from DST, the GD Birla award for scientific research. He is the fellow of three major national academies of India and served as an editorial board member of the Journal of Biological Chemistry (JBC). He was instrumental to establish the Asian Forum for Chromatin and Chromosome Biology and Chemical Biology Society, India (CBS I). At present he is the President of CBS I. Dr. Kundu is serving as a member of several scientific advisory committees of premier research institutes and funding agencies.

Dr. Chandrima Das is Associate Professor in Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics (SINP) Kolkata. Dr. Das obtained her Ph.D. from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India in 2007 with specialization in chromatin structural regulation by Nonhistone Chromatin Associated Protein (NCAP). She performed her post-doctoral research at University of Colorado Denver (2008-2010) and M D Anderson Cancer Center (2010-2012) on discovery and functional characterization of a novel human epigenetic mark, H3K56Ac. She was awarded Susan G. Komen Postdoctoral Fellowship for basic sciences in Breast Cancer Research (2009). In summer 2012, Dr. Das joined as a faculty in Saha Institute of Nuclear Physics (SINP) and established the Chromatin Dynamics Laboratory. Her focus has been on the modulation of chromatin structure by selective epigenetic recognition by a class of proteins entitled chromatin "reader/effector". She is trying to understand the diverse functions of this chromatin-binding transcription factors to dictate the on/off state of the underlying genes in different physiological conditions and pathological states like cancer, metabolic as well as infectious diseases. She has been awarded Ramalingaswami fellowship from Department of Biotechnology (2011-12), SwarnaJayanti Fellowship from Department of Science and Technology (2017-18) and S. Ramachandran - National Bioscience Award for Career Development - 2019, from Department of Biotechnology. She is an elected member of West Bengal Academy of Science and Technology (WAST), a Society that promotes basic and applied science and technology in the state of West Bengal, India. She is the Life Member of Indian Society of Cell Biology (ISCB), Indian Association for Cancer Research (IACR), Society of Biological Chemists (SBC), India, Chemical Biology Society (CBS), India and a Member of The American Society for Biochemistry and Molecular Biology (ASBMB). Recently, she has been nominated as a member of The ACS Chemical Biology Early Career Board.

Contenu
Part 1: Regulation Of Key Metabolic Pathways In Cancer.- Chapter 1: Reprogramming Carbohydrate Metabolism In Cancer And Its Role In Regulating The Tumor Microenvironment. Chapter 2: Iron In Cancer Progression: Does Bach1 Promote Metastasis By Altering Iron Homeostasis?.- Chapter 3: Regulation Of Lipid Metabolism Under Stress And Its Role In Cancer.- Chapter 4: Role Of The Histone Acetyl Transferase Mof And The Histone Deacetylase Sirtuins In Regulation Of H4k16ac During Dna Damage Repair And Metabolic Programming: Implications In Cancer And Aging.- Chapter 5: Autophagy In Cancer: A Metabolic Perspective.- Part 2: Epigenetic Regulation Of Cellular Metabolic Pathways.- Chapter 6: Long Noncoding Rnas; Lnc(Ing) Rna Metabolism, To Cancer Biology.- Chapter 7: Modulation Of Dna/Rna Methylation Signalling Mediating Metabolic Homeostasis In Cancer.- Chapter 8: Nutritional Epigenetics: How Metabolism Epigenetically Controls Cellular Physiology, Gene Expression And Disease.- Chapter 9: Epigenetic Reprogramming Of The Glucose Metabolic Pathways By The Chromatin Effectors During Cancer.- Chapter 10: Sirtuin 6 Is A Critical Epigenetic Regulator Of Cancer.- Chapter 11: Epigenetic Regulation During Hypoxia And Its Implications In Cancer.- Part 3: Epigenetic Regulation In Cancer.- Chapter 12: Metabolic Regulation Of Lysine Acetylation: Implications In Cancer.- Chapter 13: The Cross-Talk Between Epigenetic Gene Regulation And Signaling Pathways Regulates Cancer Pathogenesis.- Chapter 14: Epigenetic Regulation Towards Acquired Drug Resistance In Cancer.- Chapter 15: Structural Basis Of Targeted Imaging And Therapy In Cancer- Explorations With The Epigenetic Drugs.- Chapter 16: Epigenetic Small Molecule Modulators Targeting Metabolic Pathways In Cancer.- Chapter 17: Modulation Of Dna/Rna M…