Metabolic Interaction in Infection

This book focuses on hostpathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

State-of-the art guide of metabolism focused on host-pathogen interactions Characterization of the emerging role of immunometabolism during infections Comparative description of microbial auxotrophy and host cell metabolic rewiring by pathogens; Current status and future perspectives on the clinical application of cell metabolism evaluation in infectious contexts

Auteur
Ricardo Silvestre is Principal Investigator at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research interest is to integrate the study of basic molecular and cellular mechanisms to develop a greater understanding of the immune-metabolic interface in innate immune cells. He addresses how the modifications of host cell metabolism and bioenergetics arising during inflammatory or infectious processes impact the immune functions of monocytes/macrophage and dendritic cells and the further consequences to tissue homeostasis with the objective of developing new approaches to prevention and treatment.
Egídio Torrado is Assistant Researcher at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research is focused on the mechanisms that regulate the protective immune response to Mycobacterium tuberculosis both during the innate and chronic phases of the infection. The emphasis of his work is on cytokines and the maintenance of the T cell response and the development of pathological consequences to the host.

Contenu
Part I: A guide of metabolism during host-pathogen interactions.- 1. Cellular metabolism at a glance.- 2. Interaction between nutrition and metabolism.- 3. Interplay between metabolic sensors and cell signaling.- 4. Alterations on cellular redox states upon infection and implications for host cell homeostasis.- 5. Mitochondrial bioenergetics and dynamics during infection.- 6. Computational systems biology of metabolism in infection.- 7. Metabolomic-based methods in diagnosis and monitoring infection progression.- Part II: Microbial metabolic adaptation and pathogen rewiring of host cell metabolism during infection.- 8. Metabolic host response to intracellular infections.- 9. Protozoan parasites auxotrophies and metabolic dependencies.- 10. Viral manipulation of the host metabolic network.- 11. Metabolic regulation of innate immunity to fungal infection.- 12. Metabolic crosstalk between host and parasitic pathogens.- 13. Microbiome and gut dysbiosis. <p