Offering today's most authoritative, comprehensive coverage of sleep disorders, Kryger's Principles and Practice of Sleep Medicine, 7th Edition, is a must-have resource for sleep medicine specialists, fellows, trainees, and technicians, as well as pulmonologists, neurologists, and other clinicians who see patients with sleep-related issues. It provides a solid understanding of underlying basic science as well as complete coverage of emerging advances in management and treatment for a widely diverse patient population. Evidence-based content, hundreds of full-color illustrations, and a wealth of additional resources online help you make well-informed clinical decisions and offer your patients the best possible care.

Contenu

1 Normal Sleep and Its Variants 1. History of Sleep Physiology and Medicine 2. Normal Human Sleep: An Overview 3. Normal Aging 4. Daytime Sleepiness and Alertness 5. Sleep Deprivation

2 Sleep Mechanisms and Phylogeny 6. Introduction/Defining Sleep 7. Neural Control of Sleep in Mamma Is 8. Rapid Eye Movement Sleep Control and Function 9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep 10. Evolution of Mammalian Sleep 11. Sleep in Nonmammalian Vertebrates

3 Genetics and Genomic Basis of Sleep 12. Introduction: Genetics and Genomics of Sleep 13. Genetics and Genomics of Circadian Clocks 14. Genetics and Genomic Basis of Sleep in Simple Model Organisms 15. Genetic and Genomic Basis of Sleep in Rodents 16. Genetics and Genomic Basis of Sleep in Healthy Humans 17. Genetics and Genomic Basis of Sleep Disorders in Humans

4 Physiology in Sleep 18. Introduction to Physiology in Sleep 19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep 20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation 21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders 22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep 23. Respiratory Physiology Understanding the Control of Ventilation 24. Physiology of Upper and lower Airways 25. 5 Respiratory Physiology Sleep at High Altitude 26. Sleep and Host Defense 27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances 28. Thermoregulation in Sleep and Hibernation 29. Memory Processing in Relation to Sleep 30. Sensory and Motor Processing during Sleep and Wakefulness 31. Local and Use-Dependent Aspects of Sleep 32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury

5 Chronobiology 33. Introduction 34. Master Circadian Clock and Master Circadian Rhythm 35. Anatomy of the Mammalian Circadian Sys tern 36. Physiology of the Mammalian Circadian System 37. Human Circadian Timing System and Sleep-Wake Regulation 38. Sleep Homeostasis and Models of Sleep Regulation 39. Circadian Rhythms in Sleepiness, Alertness, and Performance 40. Central and Peripheral Circadian Clocks 41. Circadian Dysregulation and Cardiometabolic and Immune Health 42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health 43. Circadian Disorders of the Sleep-Wake Cycle

6 Pharmacology 44. Introduction 45. Adenosinergic Control of Sleep 46. Catecholamines 47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias 48. Histamine 49. Orexin/Hypocretin 50. Serotonin and Sleep 51. Melatonin 52. Opioid Actions on Sleep and Breathing 53. Clinical Pharmacology of Drugs that Affect Sleep and Wake

7 Psychobiology and Dreaming 54. Introduction 55. Why We Dream 56. Dream Content: Quantitative Findings 57. Neural Correlates of Dreaming 58. The Neurobiology of Dreaming 59. Lucid Dreaming 60. What Is the Function of Nightmares? 61. Dreams and Nightmares in Posttraumatic Stress Disorder 62. Incorporation of Waking Experiences into Dreams 63. Emotion, Motivation, and Reward in Relation to Dreaming 64. Dreaming during Pregnancy

8 Impact, Presentation, and Diagnosis 65. Approach to the Patient with Disordered Sleep 66. Cardinal Manifestations of Sleep Disorders 67. Physical Examination in Sleep Medicine 68. Clinical Tools and Tests in Sleep Medicine 69. Classification of Sleep Disorders 70. Epidemiology of Sleep Medicine 71. Sleep Medicine, Public Policy, and Public Health

9 Legal Aspects of Sleep Medicine 72. Introduction 73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence 74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them 75. Legal Aspects of Fatigue- and Safety-Sensitive Professions 76. Sleep Medicine Clinical Practice and Compliance- United States 77. Sleep Medicine Clinical Practice and Compliance-Europe

10 Occupational Sleep Medicine 78. Introduction 79. Performance Deficits During Sleep Loss and Their Operational Consequences 80. Sleep and Sleep Disorders in Operational Settings 81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder 82. Fatigue Countermeasures 83. Sleep, Sleepiness, and Performance Prediction Modeling 84. Fatigue RiskManagemen f Systems 85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue RiskManagemenf 86. Fatigue Proofing 87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions 88. Assessment of the Occupational Sleep Medicine Field

11 Insomnia 89. Advances in Insomnia Pathophysiology and Treatment: An Introduction 90. Insomnia: Epidemiology, Risk Factors, and Health Disparities 91. Etiology and Pathophysiology of Insomnia 92. Pediatric Insomnia and Its Developmental Trajectories 93. Insomnia Diagnosis, Assessment, and Evaluation 94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health 95. Behavioral Treatment I: Therapeutic Approaches and Implementation 96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination 97. Behavioral Treatment III: Digital and Telehealth Approaches 98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation 99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications 100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia

12 Neurologic Disorders 101. Introduction 102. Parkinsonism 103. Sleep-Wake Disturbances and Stroke 104. Sleep and Neuromuscular Diseases 105. Alzheimer Disease and Other Demen tias 106. Epilepsy, Sleep, and Sleep Disorders 107. Sleep and Headache 108. Sleep Disorders after Traumatic Brain Injury 109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)

13 Hypersomnias 110. Central Disorders of Hypersomnolence 111. Narcolepsy: Pathophysiology and Genetic Predisposition 112. Narcolepsy: Diagnosis and Management 113. Idiopathic Hypersomnia 114. Kleine-Levin Syndrome

14 Parasomnias 115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach 116. Disorders of Arousal 117. Sleep-Related Eating Disorder 118. Rapid Eye Movement Sleep Parasomnias 119. Nightmares and Dream Disturbances 120. Other Parasomnias 121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep 122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations

15 Sleep Breathing Disorders 123. Introduction 124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology 125. Central Sleep Apnea: Diagnosis and Management 126. Anatomy and Physiology of Upper Airway Obstruction 127. Snoring and Pathologic Upper Airway Resistance Syndromes 128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics 129. Deep Phenotyping of Sleep Apnea 130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea 131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management 132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea 133. Pharmacologic Treatments for Obstructive Sleep Apnea 134. Alternative Strategies to Management of Sleep-Disordered Breathing 135. Brain He…