Biomateriomics

Using the principles of Materiomics, this book draws links between biological processes, structures, and properties at multiple scales and their interactions. Builds on recent advances in materials science, protein science, linguistics, mathematics and more.

Biomateriomics is the holistic study of biological material systems. While such systems are undoubtedly complex, we frequently encounter similar components -- universal building blocks and hierarchical structure motifs -- which result in a diverse set of functionalities. Similar to the way music or language arises from a limited set of music notes and words, we exploit the relationships between form and function in a meaningful way by recognizing the similarities between Beethoven and bone, or Shakespeare and silk. Through the investigation of material properties, examining fundamental links between processes, structures, and properties at multiple scales and their interactions, materiomics explains system functionality from the level of building blocks.

Biomateriomics specifically focuses the analysis of the role of materials in the context of biological processes, the transfer of biological material principles towards biomimetic and bioinspired applications, and the study of interfaces between living and non-living systems. The challenges of biological materials are vast, but the convergence of biology, mathematics and engineering as well as computational and experimental techniques have resulted in the toolset necessary to describe complex material systems, from nano to macro. Applying biomateriomics can unlock Nature's secret to high performance materials such as spider silk, bone, and nacre, and elucidate the progression and diagnosis or the treatment of diseases. Similarly, it contributes to develop a de novo understanding of biological material processes and to the potential of exploiting novel concepts in innovation, material synthesis and design.

Introduces a holistic approach to the study of biological and bioinspired materials and systems Discusses the development of integrated mechanical models and experiments for hierarchical biomaterials Covers recent advances in understanding of multiscale deformation and failure of biomaterials Endorses interdisciplinary methods of research Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras

Auteur

Markus J. Buehler is Esther and Harold E. Edgerton Associate Professor, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology. He has many awards and honors to his name as well as numerous scientific papers and book chapters. He is the author of 'Atomistic Modeling of Materials Failure' published by Springer in 2008.

His research interests are in materials science and mechanics of protein materials; interaction of chemistry and mechanics; development of multi-scale simulation tools.

Texte du rabat

Biomateriomics introduces a comprehensive toolset and detailed case studies that can unlock Nature's secret to high performance materials such as spider silk, bone, and nacre. It aims to elucidate the role of materials in the progression, diagnosis and treatment of diseases, and how such understanding can pave the way for new, bioinspired material systems. Focusing on the examination of universal links between processes, structures, and properties across multiple scales the materiome this book demonstrates how system functionality and system failure can be explained from the level of building blocks and their fundamental interactions.

The ongoing convergence of biology, mathematics and engineering as well as computational and experimental techniques have resulted in the toolset necessary to describe complex material systems, from nano to macro, from molecules to function. Case studies include the analysis of key biological materials, the transfer of biological material principles towards biomimetic and bioinspired applications, and the exploration of diseases in which materials failure plays a critical role. Readers will find an analytical discussion of the experimental and numerical techniques along with a review of required biological, mathematical and physics fundamentals.

Providing an extensive review of a range of hierarchical biological materials, Biomateriomics is a valuable reference for materials scientists and engineers interested in the progress of ideas and future research challenges in biomaterials.

Contenu
Part I: A Materiomics Perspective.- The Materiome.- Biological Materials: A Biomateriomics Approach.- Music, Linguistics and Hierarchical Materials and Universality-Diversity Paradigm.- Part II: Methods and Tools .- Theory, Computational Approaches and Simulation.- Experimental Approaches.- Example: Mechanical Characterization through Experiment, Theory and Simulation.- Part III: Applied Biomateriomics.- Pathological Materiomics.- Synthesis and Design.- Conclusion, and Future of Biomateriomics.