Norman's Organic Synthesis, Fourth Edition

Auteur
Professor Mark Bagley was educated at the University of Oxford (BA 1991; DPhil 1994 with Prof L M Harwood), with post-doctoral studies at the Université de Genève (with Prof W Oppolzer), Loughborough and Exeter (with Prof C J Moody), before being appointed as a Lecturer in Organic Chemistry at Cardiff University in 1999. He stayed at Cardiff for 13 years, being promoted to a Senior Lecturereship in Organic Chemistry in 2004 and a Reader in 2006, before taking up his current position as Professor of Organic Chemistry at the University of Sussex in February 2012. He is the Professor of Organic Chemistry in the School of Life Sciences. He delivers many of the taught modules in Synthetic Organic Chemistry as part of the Chemistry degree programmes offered by the University and leads a vibrant research team in the School. Prof Bagley also serve as Chair of the Chemistry Exam Board. Professor James M Coxon: B.Sc. 1962 University of New Zealand; M.Sc.(lst class) 1963; Ph.D. 1965, University of Canterbury. Post Doctoral Fellow University of Southampton, 1966. FNZIC FRSNZ

Résumé

From the spectroscopy of molecules to energy changes, chemical principles underlie all that we see and do. Yet organic synthesis seems to stand apart, as a hugely creative and artistic pursuit of a structural target from a seemingly infinite palette of chemical transformations. This book assumes an eagerness to learn and aims simply to nurture a synoptic approach to the mastery of the subject. The distinction between novice and virtuoso has the understanding of key chemical principles at its heart - the ability to connect them to experimental observations and an elegant model of mechanism, as well as having the confidence to blend those wonderful colours to make a masterpiece.

Contenu

Chemical Thermodynamics. Molecular Structure. Chemical Kinetics. Acidity and Basicity. Mechanism. Reaction Types. Reactivity of Functional Groups. Stereochemistry. Mechanism and Kinetics. Structure Determination. Retrosynthesis. Principal Transformations in Organic Synthesis. Formation of Aliphatic C-N Bonds. Formation of Aliphatic C-C Bonds. Electrophilic Aromatic Substitution. Nucleophilic Aromatic Substitution. Aromatic Diazonium Salts. Oxidation. Reduction. Rearrangements. Free Radical Reactions. Synoptic Approaches in Organic Synthesis. Determination of Reaction Mechanism. Pericyclic Reaction. Photochemical Reactions. P, S, Si and B Reagents. Organotransition Metal Reagents. Asymmetric Synthesis. Synthesis of 5- and 6-membered Heterocycles. Synthesis of Natural Compounds I: Carbohydrates; Amino-acids, Peptides and Proteins. Synthesis of Natural Compounds.