Seeking Molecular Biomarkers for Schizophrenia Using ROC Analysis

Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases.

Summarizes the main hypotheses of the pathophysiology of SSD and that have driven associated biomarkers discovery Highlights research from the last twelve years to develop predictive, diagnostic, theranostic, or transdiagnostic models Discusses how the literature has addressed the development of new discriminatory biomarkers to achieve robust results

Auteur

Margareth Borges Coutinho Gallo holds a PhD in Chemistry from the Federal University of São Carlos. Over the past 14 years, she has dedicated her expertise in the development and validation of analytical methods at the Oswaldo Cruz Foundation (FIOCRUZ). Currently, she serves as a postdoctoral researcher specializing in metabolomics at the State University of Campinas (UNICAMP) in Brazil.

Contenu

Preface.- Hypotheses of the Pathophysiology of Schizophrenia Spectrum Disorders.- Biomarkers.- Biomarkers Related to the Hypotheses of the Pathophysiology of SSD.- Immunoinflammatory and Oxidative-Stress Related Biomarkers.- Gut Microbiota-Brain Axis and Related Biomarkers.- Neuroendocrine Biomarkers.- Neurotrophic Biomarkers.- Neurotransmitter Biomarkers.- Conclusions.- Step-by-Step Guide to Building a Diagnostic Model Using MetaboAnalyst.- Index.