Lipid Signaling in Human Diseases

The goal of this book is to review the current status of the field of lipid signaling focused on translational significance / inhibitors with the prospect to be clinically relevant for human disease

The book combines both basic principles and applied agents with clinical significance for lipid cell signaling, phospholipases and lipid kinases, lipid metabolism and trafficking, and bioactive lipids, creating a volume broad enough to attract a wide readership Drug development and novel application ideas, such as enzyme inhibitors or receptors antagonists in preclinical or current clinical trials are incorporated where possible

Reviews the current status of the field of lipid signaling focused on translational significance with the prospect to be clinically relevant for human disease The book combines both basic principles and applied agents with clinical significance for lipid cell signaling, phospholipases and lipid kinases, lipid metabolism and trafficking, and bioactive lipids Drug development and novel application ideas are incorporated where possible

Contenu
Part 1 . New Roles for Sphingolipid Signaling and Cell Function.- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.- 2. Exploring the Therapeutic Landscape of Sphingomyelinases.- 3. Sphingosine kinases as druggable targets.- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease.- 4. Prospects for PLD inhibition in cancer and thrombotic disease.- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer.- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease.- Part 3 . Lipid Kinases and Novel Regulatory Pathways.- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.- 8. Functions of Nuclear Polyphosphoinositides.- Part 4 . Bioactive Lipids in Health and Disease.- 9. Platelet-Activating Factor as an Effector for Environmental Stressors.- 10. Phospholipase D and Choline Metabolism.- Part 5 - Lipids and Membrane Microdomains.- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology.- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs.- Part 6 . Nuclear Trafficking of Lipids.- 13. Inositide-Dependent Nuclear Signalling in Health and Disease.- 14. Lipids in Exosome Biology.