Kratom

Texte du rabat

Kratom: History, Science and Therapeutic Potential is the first book to address the unregulated, widespread availability of kratom, with its weak opioid and stimulant effects, coupled with limited awareness of it by healthcare professionals. Kratom has great therapeutic utility and medicinal potential, but more study, caution, and possible regulation is needed. It discusses geographical sourcing, historical uses, current worldwide uses, and potential for treatment of other medical conditions. Most exciting for healthcare professionals will be the implications of this substance's potential for treatment of diseases like depression, ADHD, PTSD, and substance-use disorder, particularly opioid use disorder (OUD).

Moreover, kratom and its active alkaloid mitragynine are getting remarkable attention at federal and local governments as more than eight million Americans consume this product annually. Yet, the paucity of information for researchers and clinicians is troublesome.

Contenu

1. Plant sources (species and geography) and components of Kratom
   
   2. Historical uses
   3. Recent patterns and reasons for use
   4. Current legal and regulatory status
   5. Chemistry (structures, properties, computer modeling)
   6. Pharmacology (receptor binding, 2nd-messenger transduction, biased ligand)
   7. Active metabolite (7-OHM)
   8. Isolated tissue and in vivo studies (analgesia, constipation, etc.)
   9. Pharmacokinetics (ADME)
   10. Current use for self-management of SUD; withdrawal
   11. Pain and other CNS disorders
   12. Natural supplements and direct-to-consumer Kratom sales
   13. IP on naturally occurring alkaloids
   14. Drug-drug interactions
   15. Susceptible populations
   16. Purity and other quality control issues
   17. Kratom entrepreneurship
   18. Equity investment into the space
   19. Medical marijuana as template for kratom