Textbook of Personalized Medicine

Tailored to the growing interest in personalized medicine, this text summarizes the author's efforts in the field during the past decade, as well as reviews selected studies done during this period in a readable format for both physicians and scientists.

Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic.

There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine , summarizes the author's efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

Includes supplementary material: sn.pub/extras

Auteur

Professor K. K. Jain is trained in neurosurgery with specialist qualifications. He worked for 25 years in various academic positions and private practice worldwide mostly in Canada and the US. His clinical research interests during these years were use of lasers for microneurosurgery and hyperbaric oxygen. He has been involved in biotechnology since 1989, when he moved to Basel, Switzerland. He was elected a fellow of the Faculty of Pharmaceutical Medicine of the Royal Colleges of UK in 2000. He is the author of over 405 publications including 15 books and 48 special reports. Important books are Textbook of Gene Therapy, Textbook of Hyperbaric Medicine and Handbook of Nanomedicine. He is a member of editorial board of several journals and senior associate editor of MedLink Neurology (San Diego, California), a continuing education program for neurologists. Prof. Jain has been interested in integrating various biotechnologies to develop personalizedmedicine since 1997. He wrote the first report on personalized medicine, which was published in 1998 by Decision Resources Inc. The report titled Personalized Medicine: scientific and commercial aspects is continuously updated and published at Jain PharmaBiotech, Basel. He lectures and conducts workshops worldwide.

Texte du rabat

Personalized medicine is the concept that selection of a treatment should be tailored according to the individual patient's specific characteristics, including age, gender, height/weight, ethnicity, diet, and environment , versus a decision based on 'standards of care' derived by averaging responses across large cohorts of individuals in clinical trials. This alternate approach has only been possible as a result of the translation and integration of several new technologies in clinical care. As the first definitive work on this topic, Textbook of Personalized Medicine reviews the fundamentals and development of personalized medicine, and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues. The textbook will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries, and interested members of the public.

Contents:
Basics of Personalized Medicine
Molecular Diagnostics as Basis of Personalized Medicine
Role of Biomarkers in Personalized Medicine
Pharmacogenetics
Pharmacogenomics
Pharmacoproteomics
Metabolomics
Personalized Biological Therapies
Development of Personalized Therapy
Personalized Therapy of Cancer
Personalized Management of Cardiovascular Disorders
Personalized Management of Miscellaneous Disorders
Personalized preventive medicine
Organization of Personalized Medicine
Ethical and Regulatory Aspects of Personalized Medicine
Economics of Personalized Medicine
Future of Personalized Medicine

About the Author

Professor K. K. Jain is trained in neurosurgery with specialist qualifications. He worked for 25 years in various academic positions and private practice worldwide mostly inCanada and the US. His clinical research interests during these years were use of lasers for microneurosurgery and hyperbaric oxygen. He has been involved in biotechnology since 1989, when he moved to Basel, Switzerland. He was elected a fellow of the Faculty of Pharmaceutical Medicine of the Royal Colleges of UK in 2000. He is the author of over 405 publications including 15 books and 48 special reports. Important books are Textbook of Gene Therapy, Textbook of Hyperbaric Medicine and Handbook of Nanomedicine. He is a member of editorial board of several journals and senior associate editor of MedLink Neurology (San Diego, California), a continuing education program for neurologists. Prof. Jain has been interested in integrating various biotechnologies to develop personalized medicine since 1997. He wrote the first report on personalized medicine, which was published in 1998 by Decision Resources Inc. The report titled Personalized Medicine: scientific and commercial aspects is continuously updated and published at Jain PharmaBiotech, Basel. He lectures and conducts workshops worldwide.

Contenu
Basics of Personalized Medicine.- Molecular Diagnostics as Basis of Personalized Medicine.- Role of Biomarkers in Personalized Medicine.- Pharmacogenetics.- Pharmacogenomics.- Role of Pharmacoproteomics.- Role of Metabolomics in Personalized Medicine.- Personalized Biological Therapies.- Development of Personalized Medicine.- Personalized Therapy for Cancer.- Personalized Management of Neurological Disorders.- Personalized Therapy of Cardiovascular Diseases.- Personalized Management of Miscellaneous Disorders.- Personalized Preventive Medicine.- Organization of Personalized Medicine.- Ethical and Regulatory Aspects of Personalized Medicine.- Economics of Personalized Medicine.- Future of Personalized Medicine.