Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics

This book presents a unique concept of merging nanotechnology and novel urinary biomarkers for accurate early prostate cancer detection, discussing an entire progressive pipeline of innovative new strategies in biosensor development, from a simple colorimetric system to a complex system for simultaneous multiple biomarker sensing. For newcomers to the field of nucleic acid biosensing, it also describes various isothermal amplification and amplification-free strategies, which are currently the main research areas. Lastly, the book introduces and demonstrates the notion of clinical nanobiosensor validation toward clinical translation: the ultimate aim of researchers in the biosensor field. This book is a valuable reference resource learners seeking inspiration for cancer biosensor development.

Nominated as an outstanding PhD thesis by the Australian Institute for Bioengineering and Nanotechnology Describes the design of various novel nano-strategies for prostate cancer detection Offers an extensive investigation into the use of next-generation urinary biomarkers Includes data on clinical evaluation to progress clinical translation

Contenu

Unifying Next-Generation Biomarkers and Nanodiagnostic Platforms for Precision Prostate Cancer (PCa) Management.- Colorimetric Gene Fusion Diagnostics for Visual Binary Readout.- Label Free Surface-Enhanced Raman Scattering Detection System for Clinical Biomarker Targets.- Amplification-Free Electrochemical RNA Biomarker Sensing.- Simultaneous Analysis of Multiple Biomarkers via High-Throughput Parallel Profiling.