Non-motor Symptoms of Parkinson's Disease

Highly commended at the BMA Medical Book Awards 2015 This new edition summarizes the current understanding of non-motor symptoms (NMS) in Parkinson's disease and will point the way towards future research.

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians.

The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future.

Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Review from previous edition ...this is a valuable reminder that there are many non-motor symptoms that can be just as distressing.

Préface
Highly commended at the BMA Medical Book Awards 2015

Auteur

K. Ray Chaudhuri, Head and Co-Medical Director, National Restless Legs Syndrome Clinic and National Parkinson Foundation Center of Excellence, Kings College Hospital, Ruskin Wing, Denmark Hill, London, UK, Eduardo Tolosa, Professor of Neurology and Director of Parkinson Disease and Movement Disorder, University of Barcelona, Barcelona, Spain, Anthony H. V. Schapira, Chairman of the University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, , Werner Poewe, Chairman, Department of Neurology, Medical University Innsbruck, Innsbruck, Austria

Texte du rabat

This new edition summarizes the current understanding of non-motor symptoms (NMS) in Parkinson's disease and will point the way towards future research.

Résumé
Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Contenu

• Section 1 NMS: General concepts

• 1: K. Ray Chaudhuri and Niall Quinn: What are the non-motor symptoms of Parkinson's disease?

• 2: David A. Gallagher and Anthony H. V. Schapira: Non-motor symptoms and pre-motor diagnosis of Parkinson's disease

• 3: Eduardo Tolosa, Carles Gaig, Joan Santamaria and Yaroslau Compta: Non-motor symptoms in the early motor stages of Parkinson's disease

• 4: Miguel Coelho, Joaquim J Ferreira: Non-motor symptoms in advanced Parkinson's disease

• 5: Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Maria João Forjaz: Assessment tools for non-motor symptoms of Parkinson's disease in the clinical setting

• 6: David J. Brooks and Nicola Pavese: Imaging non-motor aspects of Parkinson's disease

• 7: Meike Kasten and Christine Klein: Non-motor signs in genetic forms of Parkinson's disease

• Section 2: Specific NMS of PD

• 8: Daisy L. Whitehead and Richard. G. Brown: Cognitive dysfunction of Parkinson's disease

• 9: David A. Gallagher and Anette Schrag: Depression, anxiety and apathy in Parkinson's disease

• 10: David J. Burn and Alison J. Yarnall: Dementia in Parkinson's disease

• 11: Benzi M. Kluger and Joseph H. Friedman: Fatigue in Parkinson's disease

• 12: Christopher G. Goetz, Nico J. Diederich and Gilles Fénelon: Psychosis in Parkinson's disease

• 13: Lynn Marie Trotti and David B. Rye: Neurobiology of sleep: The role of dopamine in Parkinson's disease related sleep disorders

• 14: Alex Iranzo and Eduard Tolosa: REM sleep behaviour disorder in Parkinson's disease

• 15: William G. Ondo: Parkinson's disease and restless legs syndrome

• 16: Birgit Frauscher and Werner Poewe: Excessive daytime sleepiness in Parkinson's disease

• 17: Ryuji Sakakibara and Clare Fowler: Bladder dysfunction in Parkinson's disease

• 18: Orna Moore, Gila Bronner, Sharon Hassin-Baer and Nir Giladi: Sexuality in Parkinson's disease

• 19: Fabrizio Stocchi and Margherita Torti: Gastrointestinal dysfunctions in Parkinson's disease

• 20: Italo Biaggioni and Horacio Kaufmann: Postural hypotension in Parkinson's disease

• 21: Julia Johnson , Marian L. Evatt and K. Ray Chaudhuri: Sialorrhoea in Parkinson's disease

• 22: Heinz Reichmann and Birgit Herting: Olfaction in Parkinson's disease

• 23: Santiago Perez-Lloret, Estelle Dellapina, Jean Pelleprat, María Verónica Rey, Christine Brefel-Courbon and Olivier Rascol: Chronic pain and Parkinson's disease

• 24: T. Baba, I. Estrada-Bellmann, E. Mori and A. Takeda: Visual function in Parkinson's disease

• Section 3: Quality of Life, Comorbidity, drug effects and surgery

• 25: Pablo Martinez-Martin, Francisco J. Carod Artal and Jesus de Pedro Cuesta: Non-motor symptoms and health-related quality of life: an overview

• 26: Graeme J. A. Macphee and Douglas G. MacMahon: Non motor symptoms and co-morbidity in Parkinson's disease

• 27: Shen-Yang Lim, Elena Moro, Ai Huey Tan and Anthony E. Lang: Non-motor symptoms of Parkinson's disease and the effects of deep brain stimulation surgery

• 28: Regina Katzenschlager and Andrew Evans: Impulse dyscontrol and dopamine dysregulation syndrome

• 29: Vincent Ries, J. Carsten Möller, Marcus M. Unger and Wolfgang H. Oertel: Treatment-related non-motor symptoms in Parkinson's disease

• 30: Giovanni Mostile and Joseph Jankovic: Thermoregulatory dysfunction in Parkinson's disease

• 31: Reddy P, Antonini A and Odin P: The role of continuous dopaminergic stimulation in the management of non-motor symptoms in Parkinson's disease